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Encyclopedia of Signaling Molecules pp 2217–2224Cite as

GPR56/ADGRG1

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Synonyms

ADGRG1; Cyt28; GPR56; G protein coupled receptor 56; TM7XN1

Historical Background

The family of adhesion G protein coupled receptors (aGPCRs) is the second largest class of GPCRs with increasingly recognized functions in development and disease. Structurally, aGPCRs are characterized by the presence of an extremely long N-terminal region that contains a GPCR autoproteolysis-inducing (GAIN) domain and seven transmembrane spanning regions. Most aGPCRs undergo GAIN domain-mediated autoproteolytic processing to generate an N- and a C-terminal fragment. GPR56/ADGRG1, a member of the adhesion GPCR family, was first cloned in 1999 by two independent groups, one searching for further members of the secretin family of GPCRs and the other screening for differentially expressed genes in a human melanoma metastasis model (Liu et al. 1999; Zendman et al. 1999). However, the function of GPR56 was not known until the discovery of its loss of function mutations linked to an autosomal...

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Author information

Authors and Affiliations

  1. Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Paulomi Mehta & Xianhua Piao

Authors
  1. Paulomi Mehta
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  2. Xianhua Piao
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Corresponding author

Correspondence to Xianhua Piao .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Mehta, P., Piao, X. (2018). GPR56/ADGRG1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101608

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