Skip to main content

GIPC

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules
  • 66 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arango-Lievano M, Sensoy O, Borie A, Corbani M, Guillon G, Sokoloff P, et al. A GIPC1-palmitate switch modulates dopamine Drd3 receptor trafficking and signaling. Mol Cell Biol. 2016;36:1019–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bunn R, Jensen M, Reed B. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell. 1999;10:819–32.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cai H, Reed RR. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J Neurosci. 1999;19:6519–27.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, et al. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nat Commun. 2011;2:201.

    Article  PubMed  CAS  Google Scholar 

  • De Vries L, Lou X, Zhao G, Zheng B, Farquhar MG. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci USA. 1998;95:12340–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Duman D, Tekin M. Autosomal recessive nonsyndromic deafness genes: a review. Front Biosci. 2012;17:2213–36.

    Article  CAS  PubMed Central  Google Scholar 

  • Favre-Bonvin A, Reynaud C, Kretz-Remy C, Jalinot P. Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. J Virol. 2005;79:4229–37.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gao Y, Li M, Chen W, Simons M. Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J Cell Physiol. 2000;184:373–9.

    Article  PubMed  CAS  Google Scholar 

  • Jeanneteau F, Guillin O, Diaz J, Griffon N, Sokoloff P. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. Mol Biol Cell. 2004;15:4926–37.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Katoh M. Functional proteomics, human genetics and cancer biology of GIPC family members. Exp Mol Med. 2013;45:e26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kirikoshi H, Katoh M. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. Int J Oncol. 2002;20:571–6.

    PubMed  CAS  Google Scholar 

  • La Torre A, Hoshino A, Cavanaugh C, Ware CB, Reh TA. The GIPC1-Akt pathway is required for the specification of the eye field in mouse embryonic stem cells. Stem Cells. 2015;33:2674–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ligensa T, Krauss S, Demuth D, Schumacher R, Camonis J, Jaques G, et al. A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor. J Biol Chem. 2001;276:33419–27.

    Article  PubMed  CAS  Google Scholar 

  • Liu M, Horowitz A. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol Biol Cell. 2006;17:1880–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lou X, Yano H, Lee F, Chao MV, Farquhar MG. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol Biol Cell. 2001;12:615–27.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, et al. Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clin Cancer Res. 2009;15:4095–103.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008;411:211–26.

    Article  PubMed  CAS  Google Scholar 

  • Razanskas R, Sasnauskas K. Interaction of hepatitis B virus core protein with human GIPC1. Arch Virol. 2010;155:247–50.

    Article  PubMed  CAS  Google Scholar 

  • Reed BC, Cefalu C, Bellaire BH, Cardelli JA, Louis T, Salamon J, et al. GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell. 2005;16:4183–201.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rehman AU, Gul K, Morell RJ, Lee K, Ahmed ZM, Riazuddin S, et al. Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p. Hum Genet. 2011;130:759–65.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P. The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. Oncogene. 1998;16:643–54.

    Article  PubMed  CAS  Google Scholar 

  • Rudchenko S, Scanlan M, Kalantarov G, Yavelsky V, Levy C, Estabrook A, et al. A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen. BMC Cancer. 2008;8:248.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Saitoh T, Mine T, Katoh M. Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2. Int J Oncol. 2002;20:577–82.

    PubMed  CAS  Google Scholar 

  • Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, et al. The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell. 2008;133:486–97.

    Article  PubMed  CAS  Google Scholar 

  • Tan C, Deardorff MA, Saint-Jeannet JP, Yang J, Arzoumanian A, Klein PS. Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development. Development. 2001;128:3665–74.

    PubMed  CAS  Google Scholar 

  • Wang LH, Kalb RG, Strittmatter SM. A PDZ protein regulates the distribution of the transmembrane semaphorin. M-SemF J Biol Chem. 1999;274:14137–46.

    Article  PubMed  CAS  Google Scholar 

  • Wu J, O’Donnell M, Gitler AD, Klein PS. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development. 2006;133:3651–60.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Masaru Katoh .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Katoh, M. (2018). GIPC. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101607

Download citation

Publish with us

Policies and ethics