GIPC1 was cloned and characterized independently by diverse research groups as GAIP (RGS19)-interacting protein C-terminus [GIPC] (De Vries et al. 1998), GLUT1 (SLC2A1) C-terminal binding protein [GLUT1CBP] (Bunn et al. 1999), Insulin-like growth factor-1 receptor (IGF1R)-interacting protein 1 [IIP1] (Ligensa et al. 2001), Neuropilin 1 (NRP1)-interacting protein [NIP] (Cai and Reed 1999), Semaphorin 4C (SEMA4C) cytoplasmic domain-associated protein 1 [SEMCAP1] (Wang et al. 1999), Syndecan 4 (SDC4)-interacting protein [Synectin] (Gao et al. 2000), and Tax-interacting protein 2 [TIP2] (Rousset et al. 1998).
GIPC2 (Kirikoshi and Katoh 2002) and GIPC3 (Saitoh et al. 2002) were cloned and characterized as novel GIPC family members that are related to GIPC1. GIPC3 was then characterized as the causative gene for autosomal...
- Favre-Bonvin A, Reynaud C, Kretz-Remy C, Jalinot P. Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. J Virol. 2005;79:4229–37.PubMedPubMedCentralCrossRefGoogle Scholar