Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Shigeko YamashiroEmail author
  • Fumio Matsumura
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101606


Historical Background

Fascin is a monomeric actin-bundling protein that was first isolated from sea urchin coelomocytes, later isolated as 55-kDa actin-bundling protein from HeLa cells (see for review, Jayo and Parsons 2010). It has a molecular weight of 55–58,000 kDa and makes extensive actin bundles in vitro with uniform polarity. The cloning of sea urchin fascin by Bryan et al. in 1993 revealed that fascin is homologous to the Drosophila singed gene product (Bryan et al. 1993). In 1994, Duh et al. and Holthuis et al. isolated human and Xenopus homologs of fascin, respectively (Duh et al. 1994; Holthuis et al. 1994). The sequence analyses revealed that fascin proteins form a unique family of actin-bundling proteins, sharing no apparent homology with nonfascin actin-bundling proteins including...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Molecular Biology and BiochemistryNelson Labs, Rutgers UniversityPiscatawayUSA