Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • R.R. MallaEmail author
  • Seema Kumari
  • V. Gayatri Devi
  • Anil Badana
  • G. Murali Mohan
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101599


Historical Background

CD151 also known as GP-27/MER-2/PETA-3/RAPH/SFA-1/TSPAN-24 belongs to tetraspanin superfamily. It is a plasma membrane protein which forms a “tetraspanin web” and a stable laminin-binding complex with integrins α3β1: α6β1 and α3β1:α6β4 in kidney and skin (Sterk et al. 2002). It acts as a membrane receptor, forms tetraspanin-enriched microdomains (TEMs) which serve as molecular facilitator (Zoller 2009), involved in intracellular signaling (Yauch et al. 1998). It plays vital role in cell proliferation and death (Zhang et al. 2001). It is associated with differential neural development and cognitive function,...

This is a preview of subscription content, log in to check access.



This work was supported by GITAM University, Visakhapatnam, India and funded by Department of Science and Technology (DST), New Delhi, India.


  1. Armoskus C, Moreira D, Bollinger K, Jimenez O, Taniguchi S, Tsai HW. Identification of sexually dimorphic genes in the neonatal mouse cortex and hipocamus. Brain Res. 2014;1562:23–38.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Chaudhari PR, Vaidya MM. Versatile hemidesmosomal linker proteins: structure and function. Histol Histopathol. 2015;30:425–34.PubMedPubMedCentralGoogle Scholar
  3. Geary SM, Cowin AJ, Copeland B, Baleato RM, Miyazaki K, Ashman LK. The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing. Exp Cell Res. 2008;314:2165–75.PubMedCrossRefGoogle Scholar
  4. Huang Z, Miao X, Patarroyo M, Nilsson GP, Pernow J, Li N. Tetraspanin CD151 and integrin α6β1 mediate platelet-enhanced endothelial colony forming cell angiogenesis. J Thromb Haemost. 2016;14:606–18.PubMedCrossRefGoogle Scholar
  5. Ke AW, Zhang PF, Shen YH, Gao PT, Dong ZR, Zhang C, et al. Generation and characterization of a tetraspanin CD151/integrin α6β1-binding domain competitively binding monoclonal antibody for inhibition of tumor progression in HCC. Oncotarget. 2016;7:6314–22.PubMedPubMedCentralGoogle Scholar
  6. Kumari S, Devi G, Badana A, Dasari VR, Malla RR. CD151-A striking marker for cancer therapy. Biomark Cancer. 2015;7:7–11.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Kwon MJ, Park S, Choi JY, Oh E, Kim YJ, Park YH, Cho EY, Kwon MJ, Nam SJ, Im YH, Shin YK, Choi YL. Clinical significance of CD151 overexpression in subtypes of invasive breast cancer. Br J Cancer. 2012;106:923–30.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Orlowski E, Chand R, Yip J, Wong C, Goschnick MW, Wright MD, et al. A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo. J Thromb Haemost. 2009;7:2074–84.PubMedCrossRefGoogle Scholar
  9. Sadej R, Romanska H, Kavanagh D, Baldwin G, Takahashi T, Kalia N, Berditchevski F. Tetraspanin CD151 regulates transforming growth factor beta signalling: implication in tumor metastasis. Cancer Res. 2010;70:6059–70.PubMedCrossRefGoogle Scholar
  10. Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol. 2000;149:969–82.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Sterk LM, Geuijen CA, Van Den Berg JG, Claessen N, Weening JJ. Sonnenberg. Association of the tetraspanin CD151 with the laminin-binding integrins α3β1, α6β1, α6β4 and α7β1 in cells in culture and in vivo. J Cell Sci. 2002;115:1161–73.PubMedPubMedCentralGoogle Scholar
  12. Voss MA, Gordon N, Maloney S, Ganesan R, Ludeman L, McCarthy K, Gornall R, Schaller G, Wei W, Berditchevski F, Sundar S. Tetraspanin CD151 is a novel prognostic marker in poor outcome endometrial cancer. Br J Cancer. 2011;104:1611–8.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Wang H-X, Li Q, Sharma C, Knoblich K, Hemler ME. Tetraspanin protein contributions to cancer. Biochem Soc Trans. 2011;39:547–52.PubMedCrossRefGoogle Scholar
  14. Yauch RL, Berditchevski F, Harler MB, Reichner J, Hemler ME. Highly stoichiometric, stable and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase and may regulate cell migration. Mol Biol Cell. 1998;9:2751–65.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Yoo SH, Lee K, Chae JY, Moon KC. CD151 expression can predict cancer progression in clear cell renal cell carcinoma. Histopathology. 2011;58:191–7.PubMedCrossRefGoogle Scholar
  16. Yue S, Mu W, Erb U, Zoller M. The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding. Oncotarget. 2015;6:2366–84.PubMedGoogle Scholar
  17. Zhang XA, Bontrager AL, Hemler ME. TM4SF proteins associate with activated PKC and link PKC to specific β1 integrins. J BiolChem. 2001;276:25005–13.Google Scholar
  18. Zoller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer. 2009;9:40–55.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • R.R. Malla
    • 1
    Email author
  • Seema Kumari
    • 2
  • V. Gayatri Devi
    • 2
  • Anil Badana
    • 2
  • G. Murali Mohan
    • 2
  1. 1.Department of Biochemistry, Cancer Biology LabUniversity Institute of Science, GITAM UniversityVisakhapatnamIndia
  2. 2.Department of Biochemistry, Cancer Biology LabUniversity Institute of Science, GITAM UniversityVisakhapatnamIndia