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Desmoglein-3

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References

  • Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67(5):869–87.

    Article  CAS  PubMed  Google Scholar 

  • Amagai M, Karpati S, Klaus-Kovtun V, Udey MC, Stanley JR. Extracellular domain of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion. J Invest Dermatol. 1994;103(4):609–15.

    Article  PubMed  CAS  Google Scholar 

  • Andl CD, Stanley JR. Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes. J Invest Dermatol. 2001;117(5):1068–74.

    Article  PubMed  CAS  Google Scholar 

  • Aoyama Y, Owada MK, Kitajima Y. A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes. Eur J Immunol. 1999;29(7):2233–40.

    Article  PubMed  CAS  Google Scholar 

  • Bektas M, Jolly PS, Berkowitz P, Amagai M, Rubenstein DS. A pathophysiologic role for epidermal growth factor receptor in pemphigus acantholysis. J Biol Chem. 2013;288(13):9447–56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS. Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem. 2005;280(25):23778–84.

    Article  PubMed  CAS  Google Scholar 

  • Berkowitz P, Hu P, Warren S, Liu Z, Diaz LA, Rubenstein DS. p38MAPK inhibition prevents disease in pemphigus vulgaris mice. Proc Natl Acad Sci USA. 2006;103(34):12855–60.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berkowitz P, Chua M, Liu Z, Diaz LA, Rubenstein DS. Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin. Am J Pathol. 2008a;173(6):1628–36.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berkowitz P, Diaz LA, Hall RP, Rubenstein DS. Induction of p38MAPK and HSP27 phosphorylation in pemphigus patient skin. J Invest Dermatol. 2008b;128(3):738–40.

    Article  PubMed  CAS  Google Scholar 

  • Brown L, Wan H. Desmoglein 3: a help or a hindrance in cancer progression? Cancers (Basel). 2015;7(1):266–86.

    Article  CAS  Google Scholar 

  • Brown L, Waseem A, Cruz IN, Szary J, Gunic E, Mannan T, Unadkat M, Yang M, Valderrama F, O’Toole EA, Wan H. Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. Oncogene. 2014;33(18):2363–74.

    Article  PubMed  CAS  Google Scholar 

  • Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo DG. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J Cell Biol. 1998;141(6):1449–65.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen YJ, Lee LY, Chao YK, Chang JT, Lu YC, Li HF, Chiu CC, Li YC, Li YL, Chiou JF, Cheng AJ. DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway. PLoS One. 2013;8(5):e64088.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chernyavsky AI, Arredondo J, Kitajima Y, Sato-Nagai M, Grando SA. Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens. J Biol Chem. 2007;282(18):13804–12.

    Article  PubMed  CAS  Google Scholar 

  • Cirillo N, AlShwaimi E, McCullough M, Prime SS. Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3. Autoimmunity. 2014;47(2):134–40.

    Article  PubMed  CAS  Google Scholar 

  • Clucas J, Valderrama F. ERM proteins in cancer progression. J Cell Sci. 2014;127(Pt 2):267–75.

    Article  PubMed  CAS  Google Scholar 

  • Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem. 1997;272(10):6525–33.

    Article  PubMed  CAS  Google Scholar 

  • Davisson MT, Cook SA, Johnson KR, Eicher EM. Balding: a new mutation on mouse chromosome 18 causing hair loss and immunological defects. J Hered. 1994;85(2):134–6.

    Article  PubMed  CAS  Google Scholar 

  • de Bruin A, Caldelari R, Williamson L, Suter MM, Hunziker T, Wyder M, Muller EJ. Plakoglobin-dependent disruption of the desmosomal plaque in pemphigus vulgaris. Exp Dermatol. 2007;16(6):468–75.

    Article  PubMed  CAS  Google Scholar 

  • Delva E, Jennings JM, Calkins CC, Kottke MD, Faundez V, Kowalczyk AP. Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism. J Biol Chem. 2008;283(26):18303–13.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Esaki C, Seishima M, Yamada T, Osada K, Kitajima Y. Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol. 1995;105(3):329–33.

    Article  PubMed  CAS  Google Scholar 

  • Frank J, Cserhalmi-Friedman PB, Ahmad W, Panteleyev AA, Aita VM, Christiano AM. Characterization of the desmosomal cadherin gene family: genomic organization of two desmoglein genes on human chromosome 18q12. Exp Dermatol. 2001;10(2):90–4.

    Article  PubMed  CAS  Google Scholar 

  • Frusic-Zlotkin M, Raichenberg D, Wang X, David M, Michel B, Milner Y. Apoptotic mechanism in pemphigus autoimmunoglobulins-induced acantholysis – possible involvement of the EGF receptor. Autoimmunity. 2006;39(7):563–75.

    Article  PubMed  CAS  Google Scholar 

  • Gil MP, Modol T, Espana A, Lopez-Zabalza MJ. Inhibition of FAK prevents blister formation in the neonatal mouse model of pemphigus vulgaris. Exp Dermatol. 2012;21(4):254–9.

    Article  PubMed  CAS  Google Scholar 

  • Gliem M, Heupel WM, Spindler V, Harms GS, Waschke J. Actin reorganization contributes to loss of cell adhesion in pemphigus vulgaris. Am J Physiol Cell Physiol. 2010;299(3):C606–13.

    Article  PubMed  CAS  Google Scholar 

  • Grando SA, Bystryn JC, Chernyavsky AI, Frusic-Zlotkin M, Gniadecki R, Lotti R, Milner Y, Pittelkow MR, Pincelli C. Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis. Exp Dermatol. 2009;18(9):764–70.

    Article  PubMed  CAS  Google Scholar 

  • Heupel WM, Engerer P, Schmidt E, Waschke J. Pemphigus vulgaris IgG cause loss of desmoglein-mediated adhesion and keratinocyte dissociation independent of epidermal growth factor receptor. Am J Pathol. 2009;174(2):475–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jolly PS, Berkowitz P, Bektas M, Lee HE, Chua M, Diaz LA, Rubenstein DS. p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis. J Biol Chem. 2010;285(12):8936–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kanno M, Isa Y, Aoyama Y, Yamamoto Y, Nagai M, Ozawa M, Kitajima Y. P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3. Exp Cell Res. 2008;314(8):1683–92.

    Article  PubMed  CAS  Google Scholar 

  • Kawasaki Y, Aoyama Y, Tsunoda K, Amagai M, Kitajima Y. Pathogenic monoclonal antibody against desmoglein 3 augments desmoglein 3 and p38 MAPK phosphorylation in human squamous carcinoma cell line. Autoimmunity. 2006;39(7):587–90.

    Article  PubMed  CAS  Google Scholar 

  • Kikuchi A, Kishida S, Yamamoto H. Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med. 2006;38(1):1–10.

    Article  PubMed  CAS  Google Scholar 

  • Kitajima Y. 150(th) anniversary series: desmosomes and autoimmune disease, perspective of dynamic desmosome remodeling and its impairments in pemphigus. Cell Commun Adhes. 2014;21(6):269–80.

    Article  PubMed  CAS  Google Scholar 

  • Kitajima Y, Aoyama Y, Seishima M. Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell datachment induced by pemphigus IgG in cultured keratinocytes: involvement of protein kinase C. J Investig Dermatol Symp Proc. 1999;4(2):137–44.

    Article  PubMed  CAS  Google Scholar 

  • Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997;137(5):1091–102.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Koch PJ, Mahoney MG, Cotsarelis G, Rothenberger K, Lavker RM, Stanley JR. Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci. 1998;111(Pt 17):2529–37.

    PubMed  CAS  Google Scholar 

  • Kong J, Li Y, Liu S, Jin H, Shang Y, Quan C, Li Y, Lin Z. High expression of ezrin predicts poor prognosis in uterine cervical cancer. BMC Cancer. 2013;13:520.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kountikov EI, Poe JC, Maclver NJ, Rathmell JC, Tedder TF. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Am J Pathol. 2015;185(3):617–30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee HE, Berkowitz P, Jolly PS, Diaz LA, Chua MP, Rubenstein DS. Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis. J Biol Chem. 2009a;284(18):12524–32.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lee JS, Yoon HK, Sohn KC, Back SJ, Kee SH, Seo YJ, Park JK, Kim CD, Lee JH. Expression of N-terminal truncated desmoglein 3 (deltaNDg3) in epidermis and its role in keratinocyte differentiation. Exp Mol Med. 2009b;41(1):42–50.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li S, Couet J, Lisanti MP. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem. 1996;271(46):29182–90.

    Article  PubMed  CAS  Google Scholar 

  • Lisanti MP, Scherer PE, Tang Z, Sargiacomo M. Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol. 1994;4(7):231–5.

    Article  PubMed  CAS  Google Scholar 

  • Mao X, Sano Y, Park JM, Payne AS. p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris. J Biol Chem. 2011;286(2):1283–91.

    Article  PubMed  CAS  Google Scholar 

  • Mao X, Li H, Sano Y, Gaestel M, Mo PJ, Payne AS. MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris. J Invest Dermatol. 2014;134(1):68–76.

    Article  PubMed  CAS  Google Scholar 

  • Novak A, Dedhar S. Signaling through beta-catenin and Lef/Tcf. Cell Mol Life Sci. 1999;56(5–6):523–37.

    Article  PubMed  CAS  Google Scholar 

  • Okamoto T, Schlegel A, Scherer PE, Lisanti MP. Caveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membrane. J Biol Chem. 1998;273(10):5419–22.

    Article  PubMed  CAS  Google Scholar 

  • Osada K, Seishima M, Kitajima Y. Pemphigus IgG activates and translocates protein kinase C from the cytosol to the particulate/cytoskeleton fractions in human keratinocytes. J Invest Dermatol. 1997;108(4):482–7.

    Article  PubMed  CAS  Google Scholar 

  • Pelacho B, Natal C, Espana A, Sanchez-Carpintero I, Iraburu MJ, Lopez-Zabalza MJ. Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes. FEBS Lett. 2004;566(1–3):6–10.

    Article  CAS  PubMed  Google Scholar 

  • Pretel M, Espana A, Marquina M, Pelacho B, Lopez-Picazo JM, Lopez-Zabalza MJ. An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris. Exp Dermatol. 2009;18(9):771–80.

    Article  CAS  PubMed  Google Scholar 

  • Pulkkinen L, Choi YW, Simpson A, Montagutelli X, Sundberg J, Uitto J, Mahoney MG. Loss of cell adhesion in Dsg3bal-Pas mice with homozygous deletion mutation (2079del14) in the desmoglein 3 gene. J Invest Dermatol. 2002;119(6):1237–43.

    Article  CAS  PubMed  Google Scholar 

  • Rotzer V, Hartlieb E, Vielmuth F, Gliem M, Spindler V, Waschke J. E-cadherin and Src associate with extradesmosomal Dsg3 and modulate desmosome assembly and adhesion. Cell Mol Life Sci. 2015;72(24):4885–97.

    Article  CAS  PubMed  Google Scholar 

  • Saito M, Stahley SN, Caughman CY, Mao X, Tucker DK, Payne AS, Amagai M, Kowalczyk AP. Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation. PLoS One. 2012;7(12):e50696.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schmidt E, Waschke J. Apoptosis in pemphigus. Autoimmun Rev. 2009;8(7):533–7.

    Article  CAS  PubMed  Google Scholar 

  • Schmidt E, Gutberlet J, Siegmund D, Berg D, Wajant H, Waschke J. Apoptosis is not required for acantholysis in pemphigus vulgaris. Am J Physiol Cell Physiol. 2009;296(1):C162–72.

    Article  CAS  PubMed  Google Scholar 

  • Schulze K, Galichet A, Sayar BS, Scothern A, Howald D, Zymann H, Siffert M, Zenhausern D, Bolli R, Koch PJ, Garrod D, Suter MM, Muller EJ. An adult passive transfer mouse model to study desmoglein 3 signaling in pemphigus vulgaris. J Invest Dermatol. 2012;132(2):346–55.

    Article  CAS  PubMed  Google Scholar 

  • Seishima M, Esaki C, Osada K, Mori S, Hashimoto T, Kitajima Y. Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line. J Invest Dermatol. 1995;104(1):33–7.

    Article  CAS  PubMed  Google Scholar 

  • Spindler V, Endlich A, Hartlieb E, Vielmuth F, Schmidt E, Waschke J. The extent of desmoglein 3 depletion in pemphigus vulgaris is dependent on Ca(2+)-induced differentiation: a role in suprabasal epidermal skin splitting? Am J Pathol. 2011;179(4):1905–16.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Thomason HA, Scothern A, McHarg S, Garrod DR. Desmosomes: adhesive strength and signalling in health and disease. Biochem J. 2010;429(3):419–33.

    Article  CAS  PubMed  Google Scholar 

  • Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H. Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PLoS One. 2010;5(12):e14211.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tsang SM, Brown L, Gadmor H, Gammon L, Fortune F, Wheeler A, Wan H. Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics. Exp Cell Res. 2012a;318(18):2269–83.

    Article  CAS  PubMed  Google Scholar 

  • Tsang SM, Brown L, Lin K, Liu L, Piper K, O’Toole EA, Grose R, Hart IR, Garrod DR, Fortune F, Wan H. Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol. 2012b;227(1):81–93.

    Article  CAS  PubMed  Google Scholar 

  • Vielmuth F, Waschke J, Spindler V. Loss of desmoglein binding is not sufficient for keratinocyte dissociation in pemphigus. J Invest Dermatol. 2015;135(12):3068–77.

    Article  CAS  PubMed  Google Scholar 

  • Wan H, Lin K, Tsang SM, Uttagomol J. Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1. Data Brief. 2016;6:124–34.

    Article  PubMed  Google Scholar 

  • Wang X, Bregegere F, Frusic-Zlotkin M, Feinmesser M, Michel B, Milner Y. Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins. Apoptosis. 2004;9(2):131–43.

    Article  CAS  PubMed  Google Scholar 

  • Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D. Inhibition of Rho A activity causes pemphigus skin blistering. J Cell Biol. 2006;175(5):721–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Williamson L, Raess NA, Caldelari R, Zakher A, de Bruin A, Posthaus H, Bolli R, Hunziker T, Suter MM, Muller EJ. Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin. EMBO J. 2006;25(14):3298–309.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Williamson L, Suter MM, Olivry T, Wyder M, Muller EJ. Upregulation of c-Myc may contribute to the pathogenesis of canine pemphigus vulgaris. Vet Dermatol. 2007;18(1):12–7.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    Hong Wan

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  1. Hong Wan
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  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Wan, H. (2018). Desmoglein-3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101583

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