Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Hong WanEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101583


Historic Background

Desmoglein-3 (Dsg3) was first identified as a pemphigus vulgaris antigen (PVA) from the human keratinocyte expression libraries in 1991 by Amagai et al. in an attempt to search for the targets of pemphigus vulgaris autoantibodies (Amagai et al. 1991). Due to its significant homology with the cadherin family of cell adhesion molecules and most remarkably to Dsg1, Dsg3 is characterized as a member of cadherin superfamily and specifically the one in desmoglein subfamily which contains Dsg1. Pemphigus vulgaris (PV) is a potentially lethal autoimmune blistering disease that affects oral mucosa and skin with the manifestation of acantholysis characterized as the loss of adhesion between epithelial cells and structural components maintaining cell cohesion in the tissues caused by the action of autoantibodies against Dsg3 as well as Dsg1....

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUK