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NBCe1 Electrogenic Na+-Coupled HCO3(CO32−) Transporter

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Synonyms

Electrogenic sodium bicarbonate cotransporter 1; NBCe1

Historical Background: SLC4 Gene Transporter Family

The NBCe1 transporter belongs to the SLC4 gene family whose 10 members are homologous membrane transport proteins that differ in their ability to transport Na+, Cl, HCO3(CO32−), H+, NH3, and water (Kurtz 2013; Parker and Boron 2013; Liu et al. 2015). AE1, AE2, and AE3 (SLC4A1, −2, −3, respectively) mediate the electroneutral exchange of Cl and HCO3. The SLC4A9 gene encodes AE4 has previously been reported to function as a Cl/HCO3 exchanger and electroneutral Na+-HCO3 cotransporter, but has recently been shown to mediate electroneutral monovalent cation (Na+/K+)-dependent Cl/HCO3 exchange (Pena-Munzenmayer et al. 2016). NDCBE (encoded by SLC4A8) like AE1, AE2, and AE3 is an anion exchanger yet differs in that it couples the electroneutral transport of Na+ and HCO3 (or CO32−) in exchange for Cl. NBCn1 (SLC4A7 gene) and NBCn2 (SLC4A10 gene) transport Na+-HCO3...

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NBCe1 Electrogenic Na+-Coupled HCO3−(CO32−) Transporter, Fig. 1
NBCe1 Electrogenic Na+-Coupled HCO3−(CO32−) Transporter, Fig. 2
NBCe1 Electrogenic Na+-Coupled HCO3−(CO32−) Transporter, Fig. 3
NBCe1 Electrogenic Na+-Coupled HCO3−(CO32−) Transporter, Fig. 4
NBCe1 Electrogenic Na+-Coupled HCO3−(CO32−) Transporter, Fig. 5

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Acknowledgments

Dr. Kurtz is supported in part by funds from the NIH (R01-DK077162), the Allan Smidt Charitable Fund, the Factor Family Foundation Chair in Nephrology, and the Arvey Foundation.

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Kurtz, I. (2018). NBCe1 Electrogenic Na+-Coupled HCO3(CO32−) Transporter. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101572

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