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Encyclopedia of Signaling Molecules pp 1471–1477Cite as

E3 Ubiquitin Ligase CBL-B

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Synonyms

Casitas B Lymphoma

Historical Background

The E3 ubiquitin ligase CBL-B (Casitas Blymphoma-b) is a member of the highly conserved mammalian Cbl family consisting of c-Cbl, Cbl-b, and Cbl-3. c-Cbl is the founding member, which was first discovered in 1989 (Langdon et al. 1989), whereas Cbl-b was first cloned in 1995 (Keane et al. 1995). Both Cbl-b and c-Cbl contain an N-terminal protein tyrosine kinase binding (TKB) domain, a RING finger, a C-terminal proline-rich region (PRR) with potential tyrosine phosphorylation sites, and a ubiquitin-associated domain (UBA) (Fig. 1). With these multiple domains, c-Cbl and Cbl-b can act as adaptor proteins and forms multiple complexes with many signaling molecules to modulate intracellular signaling events.

E3 Ubiquitin Ligase CBL-B, Fig. 1
figure 61 figure 61

Cbl-b structure

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Authors and Affiliations

  1. Department of Microbial Infection and Immunity, The Ohio State University, 460 west 12th avenue, Columbus, OH, 43210, USA

    Juan Tang

  2. Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China

    Jian Zhang

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  1. Juan Tang
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  2. Jian Zhang
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Correspondence to Jian Zhang .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Tang, J., Zhang, J. (2018). E3 Ubiquitin Ligase CBL-B. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101569

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