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Encyclopedia of Signaling Molecules pp 5794–5802Cite as

Type-1 Cannabinoid Receptor

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Synonyms

CANN6; CB1A; CB1K5; CB1R; CB-R; Central cannabinoid receptor

Historical Background

The use of cannabis (Cannabis sativa) has been known for centuries, but it was necessary to wait until the late 1980s to understand the molecular basis responsible for its medical and recreational properties. Unlike cocaine and morphine, isolated as crystalline salts from coca leaves and opium respectively, the active constituent of cannabis appeared as an oily extract, difficult to isolate in pure form. Only in the 1960s isolation, characterization, and chemical synthesis of the active cannabis constituent, Δ9-tetrahydrocannabinol (THC), was possible. The identification of THC allowed a reevaluation of cannabis pharmacology and gradually boosted research towards the understanding of the molecular and cellular mechanisms underlying its therapeutic efficacy.

Although the existence of THC-binding cannabinoid receptors, and of an even more surprising ensamble of metabolic enzymes and transporters...

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Author information

Authors and Affiliations

  1. Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Italy

    Tiziana Bisogno

  2. Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128, Rome, Italy

    Tiziana Bisogno & Mauro Maccarrone

  3. European Center for Brain Research/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143, Rome, Italy

    Mauro Maccarrone

Authors
  1. Tiziana Bisogno
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  2. Mauro Maccarrone
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Corresponding authors

Correspondence to Tiziana Bisogno or Mauro Maccarrone .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Bisogno, T., Maccarrone, M. (2018). Type-1 Cannabinoid Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101565

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