Skip to main content
SpringerLink
Log in

Human MCP Chemokine Cluster

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

  • 386 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bonapace L, Coissieux MM, Wyckoff J, et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature. 2014;515:130–3.

    Article  CAS  PubMed  Google Scholar 

  • Bottazzi B, Colotta F, Sica A, Nobili N, Mantovani A. A chemoattractant expressed in human sarcoma cells (tumor-derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF). Int J Cancer. 1990;45:795–7.

    Article  PubMed  CAS  Google Scholar 

  • Cho YB, Lee WY, Choi SJ, et al. CC chemokine ligand 7 expression in liver metastasis of colorectal cancer. Oncol Rep. 2012;28:689–94.

    Article  PubMed  CAS  Google Scholar 

  • Das S, Sarrou E, Podgrabinska S, et al. Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J Exp Med. 2013;210:1509–28.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV. Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke. 2007;38:1345–53.

    Article  PubMed  CAS  Google Scholar 

  • Farmaki E, Chatzistamou I, Kaza V, Kiaris H. A CCL8 gradient drives breast cancer cell dissemination. Oncogene. 2016;35:6309–18.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fujimoto H, Sangai T, Ishii G, et al. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int J Cancer. 2009;125:1276–84.

    Article  PubMed  CAS  Google Scholar 

  • Halvorsen EC, Hamilton MJ, Young A, et al. Maraviroc decreases CCL8-mediated migration of CCR5(+) regulatory T cells and reduces metastatic tumor growth in the lungs. Oncoimmunology. 2016;5:e1150398.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Heidegger I, Hofer J, Luger M, et al. Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence? Prostate. 2015;75:1904–9.

    Article  PubMed  CAS  Google Scholar 

  • Islam SA, Chang DS, Colvin RA, et al. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol. 2011;12:167–77.

    Article  PubMed  CAS  Google Scholar 

  • Jose PJ, Griffiths-Johnson DA, Collins PD, et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med. 1994;179:881–7.

    Article  CAS  PubMed  Google Scholar 

  • Kalayci O, Sonna LA, Woodruff PG, Camargo Jr CA, Luster AD, Lilly CM. Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma. J Asthma. 2004;41:27–33.

    Article  PubMed  CAS  Google Scholar 

  • Lu X, Kang Y. Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem. 2009;284:29087–96.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Maddaluno M, Di Lauro M, Di Pascale A, et al. Monocyte chemotactic protein-3 induces human coronary smooth muscle cell proliferation. Atherosclerosis. 2011;217:113–9.

    Article  PubMed  CAS  Google Scholar 

  • McCully ML, Moser B. The human cutaneous chemokine system. Front Immunol. 2011;2:33.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nomiyama H, Mera A, Ohneda O, Miura R, Suda T, Yoshie O. Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: diversification between the two species. Genes Immun. 2001;2:110–3.

    Article  PubMed  CAS  Google Scholar 

  • Proost P, Wuyts A, Van Damme J. Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1. J Leukoc Biol. 1996;59:67–74.

    Article  PubMed  CAS  Google Scholar 

  • Rollins BJ, Sunday ME. Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. Mol Cell Biol. 1991;11:3125–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rollins BJ. Chemokines. Blood. 1997;90:909–28.

    PubMed  CAS  Google Scholar 

  • Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells. Cell Immunol. 1998;189:160–8.

    Article  PubMed  CAS  Google Scholar 

  • Ruhwald M, Bodmer T, Maier C, et al. Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis. Eur Respir J. 2008;32:1607–15.

    Article  PubMed  CAS  Google Scholar 

  • Schenk S, Mal N, Finan A, et al. Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells. 2007;25:245–51.

    Article  PubMed  CAS  Google Scholar 

  • Schweickart VL, Epp A, Raport CJ, Gray PW. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J Biol Chem. 2000;275:9550–6.

    Article  PubMed  CAS  Google Scholar 

  • Song LY, Kim SY, Song SJ, et al. Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways. Oncotarget. 2016;7:36842–53.

    PubMed  PubMed Central  Google Scholar 

  • Sozzani S, Zhou D, Locati M, et al. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J Immunol. 1994;152:3615–22.

    PubMed  CAS  Google Scholar 

  • Tian M, Chen L, Li M, et al. Expression and prognostic significance of CCL11/CCR3 in glioblastoma. Oncotarget. 2016;7:32617–27.

    PubMed  PubMed Central  Google Scholar 

  • Ueno T, Toi M, Saji H, et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res. 2000;6:3282–9.

    PubMed  CAS  Google Scholar 

  • Uguccioni M, Loetscher P, Forssmann U, et al. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. J Exp Med. 1996;183:2379–84.

    Article  PubMed  CAS  Google Scholar 

  • Wang JM, Chertov O, Proost P, et al. Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NFkappaB activation. Int J Cancer. 1998;75:900–7.

    Article  PubMed  CAS  Google Scholar 

  • Yadav A, Saini V, Arora S. MCP-1: Chemoattractant with a role beyond immunity: a review. Clin Chim Acta. 2010;411:1570–9.

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi A, Nozawa K, Fujishiro M, et al. CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis. Mod Rheumatol. 2013;23:856–63.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto M, Ota A, Hori T, et al. Early expression of plasma CCL8 closely correlates with survival rate of acute graft-vs.-host disease in mice. Exp Hematol. 2011;39:1101–12.

    Article  PubMed  CAS  Google Scholar 

  • Yanaba K, Yoshizaki A, Muroi E, et al. CCL13 is a promising diagnostic marker for systemic sclerosis. Br J Dermatol. 2010;162:332–6.

    Article  PubMed  CAS  Google Scholar 

  • Yang OO, Garcia-Zepeda EA, Walker BD, Luster AD. Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. J Infect Dis. 2002;185:1174–8.

    Article  PubMed  CAS  Google Scholar 

  • Yeh CR, Hsu I, Song W, et al. Fibroblast ERalpha promotes bladder cancer invasion via increasing the CCL1 and IL-6 signals in the tumor microenvironment. Am J Cancer Res. 2015;5:1146–57.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Zlotnik A, Yoshie O, Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol. 2006;7:243.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, CLS 709, 715 Sumter Street, Columbia, SC, 29208-3402, USA

    Elena Farmaki

  2. Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Bldg #1, Room B32, Columbia, SC, 29208, USA

    Ioulia Chatzistamou

  3. Department of Biochemistry, University of Athens Medical School, Athens, Greece

    Hippokratis Kiaris

  4. Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA

    Hippokratis Kiaris

Authors
  1. Elena Farmaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ioulia Chatzistamou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hippokratis Kiaris
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hippokratis Kiaris .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Farmaki, E., Chatzistamou, I., Kiaris, H. (2018). Human MCP Chemokine Cluster. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101562

Download citation

Publish with us

Policies and ethics

Search

Navigation