Synonyms
Historical Background
From 1970s to early 1990s, a lot of cell-cycle regulators such as cell division cycle (cdc) or radiation-sensitive (rad) genes had been identified as results of yeast genetic screenings. In 1988, through the analyses of rad9 mutants in budding yeast (Saccharomyces cerevisiae), Weinert and Hartwell first proposed a cell cycle checkpoint that prevents inappropriate progression of the cell cycle when DNA is damaged or incompletely replicated (Weinert and Hartwell 1988). In 1993, Beach and coworkers reported a novel gene that controls G2/M transition after DNA damage (G2/M checkpoint) in the fission yeast (Schizosaccharomyces pombe). Since this gene encoded a Ser/Thr protein kinase, it was named checkpoint kinase 1 (Chk1) (Walworth et al. 1993). By 1997, Chk1 orthologs were identified in budding yeast (Rad27), fruit fly (Grapes [Grp]; Drosophila melanogaster), mouse, and human (CHEK1indicates a gene locus of...
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Goto, H., Inaba, H., Inagaki, M. (2018). Chk1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101557
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101557
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