CDK5

Guo, Yumeng; Wang, Yu; Bai, Bo

doi:10.1007/978-3-319-67199-4_101554

Yumeng Guo²,
Yu Wang² &
Bo Bai²

317 Accesses

Synonyms

AW048668; CDC2-related kinase 6; Crk6; Cyclin-dependent kinase 5; NCLK; Neuronal CDC2-like kinase; PSSALRE kinase

Historical Background

Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine-protein kinase, was originally purified from bovine brain and defined as a neuronal CDC2 (CDK1)-like kinase (NCLK) (Roder and Ingram 1991; Hellmich et al. 1992). Later on, CDK5 demonstrated capability to induce the Alzheimer-like characteristics by phosphorylation of tau protein (Baumann et al. 1993). p35 (CDK5R1) was then characterized as a regulatory subunit of CDK5 to activate its kinase activity, with subsequent identification of its isoform p39 (CDK5R2) (Tsai et al. 1994; Tang et al. 1995). CDK5/p35 is the first example of a CDC2-like kinase with neuronal function. A truncated form of p35, p25, was purified with CDK5 as a hetero-dimer exhibiting activity in vitro and regarded as a novel regulatory subunit of CDK5 (Lew et al. 1994). Accumulation of p25 is found in...

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State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China
Yumeng Guo, Yu Wang & Bo Bai

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Yumeng Guo
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Yu Wang
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Bo Bai
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Department of Molecular Science and Technology, Ajou University, Suwon, Korea
Sangdun Choi

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Guo, Y., Wang, Y., Bai, B. (2018). CDK5. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101554

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Published: 01 June 2018
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