Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

C-Reactive Protein

  • Andreja Trpkovic
  • Milan Obradovic
  • Nina Petrovic
  • Radoslav Davidovic
  • Emina Sudar-Milovanovic
  • Esma R. IsenovicEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101542


Historical Background

Tillett and Francis (1930) noticed that C polysaccharide of Pneumococcus precipitated in the serum of patients with lobar pneumonia. During the acute stage of the disease, precipitation test was positive, while negative shortly after recovery. This indicated that there was a substance reactive only during the acute phase of the infectious disease which was confirmed in sera taken from children in acute phase of Gram-negative bacilli by Ash (1933). Abernethy and Francis (1937) injected C carbohydrate in patients with acute phase of pneumonia and noticed specific skin reactions associated with the effect of precipitation of C polysaccharide. Abernethy and Avery (1941) showed that serum taken from humans and monkeys contained protein that has the ability to precipitate with C polysaccharide during the acute stage of various infectious diseases, but in the presence of Ca2+. Later,...

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This work is supported by grants No.173033 (to E.R.I) from the Ministry of Science, Republic of Serbia.


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© Springer International Publishing AG 2018

Authors and Affiliations

  • Andreja Trpkovic
    • 1
  • Milan Obradovic
    • 1
  • Nina Petrovic
    • 1
  • Radoslav Davidovic
    • 1
  • Emina Sudar-Milovanovic
    • 1
  • Esma R. Isenovic
    • 1
    Email author
  1. 1.Laboratory for Radiobiology and Molecular GeneticsVinca Institute of Nuclear Sciences, University of BelgradeBelgradeSerbia