Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Vanessa LanoueEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101539


Historical Background

The adhesion G protein–coupled receptor (GPCR) BAI subfamily was uncovered in 1997 by Dr. Tokino’s laboratory. They first discovered the hBAI1 gene as a target gene for the p53 tumor suppressor in a cDNA library of fetal human brain (Nishimori et al. 1997). They subsequently identified two homologous genes: hBAI2 and hBAI3 which are not regulated by p53 (Shiratsuchi et al. 1997). This adhesion GPCR subfamily was named human brain-specific Angiogenesis inhibitor because of the capacity of BAI1 to inhibit neovascularization in a rat cornea model, and its predominant expression in the human brain. In 2015, a new nomenclature has been proposed for all the adhesion GPCRs by the Adhesion GPCR Consortium and the International Union of Basic and Clinical Pharmacology Committee. For the BAI subfamily, this new nomenclature is: ADhesion G protein–coupled Receptor B or ADGRB1–3 (Hamann et...

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  1. Antoni G, Morange P-E, Luo Y, Saut N, Burgos G, Heath S, et al. A multi-stage multi-design strategy provides strong evidence that the BAI3 locus is associated with early-onset venous thromboembolism. J Thromb Haemost. 2010;8(12):2671–9.PubMedCrossRefGoogle Scholar
  2. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis: cell-adhesion GPCRs mediates autoproteolysis. EMBO J. 2012;31(6):1364–78.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Bari MF, Brown H, Nicholson AG, Kerr KM, Gosney JR, Wallace WA, et al. BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas. Histopathology. 2014;64(4):547–56.PubMedCrossRefGoogle Scholar
  4. Bjarnadóttir TK, Geirardsdóttir K, Ingemansson M, Mirza MAI, Fredriksson R, Schiöth HB. Identification of novel splice variants of adhesion G protein-coupled receptors. Gene. 2007;387(1–2):38–48.PubMedCrossRefGoogle Scholar
  5. Bolliger MF, Martinelli DC, Südhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proc Natl Acad Sci. 2011;108(6):2534–9.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Collins MO, Husi H, Yu L, Brandon JM, Anderson CNG, Blackstock WP, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem. 2006;97:16–23.PubMedCrossRefGoogle Scholar
  7. DeRosse P, Lencz T, Burdick KE, Siris SG, Kane JM, Malhotra AK. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. Schizophr Bull. 2008;34(6):1047–53.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein–coupled receptors. Pharmacol Rev. 2015;67(2):338–67.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Hamoud N, Tran V, Croteau L-P, Kania A, Côté J-F. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Proc Natl Acad Sci. 2014;111(10):3745–50.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Ito J, Ito M, Nambu H, Fujikawa T, Tanaka K, Iwaasa H, et al. Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6 J mice. Cell Tissue Res. 2009;338(2):257–69.PubMedCrossRefGoogle Scholar
  11. Jordan BA, Fernholz BD, Boussac M, Xu C, Grigorean G, Ziff EB, et al. Identification and verification of novel rodent postsynaptic density proteins. Mol Cell Proteomics. 2004;3(9):857–71.PubMedCrossRefGoogle Scholar
  12. Kakegawa W, Mitakidis N, Miura E, Abe M, Matsuda K, Takeo YH, et al. Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Neuron. 2015;85(2):316–29.PubMedCrossRefGoogle Scholar
  13. Kan Z, Jaiswal BS, Stinson J, Janakiraman V, Bhatt D, Stern HM, et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature. 2010;466(7308):869–73.PubMedCrossRefGoogle Scholar
  14. Kee HJ, Ahn KY, Choi KC, Won Song J, Heo T, Jung S, et al. Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma. FEBS Lett. 2004;569(1–3):307–16.PubMedCrossRefGoogle Scholar
  15. Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, et al. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013;18(8):943–50.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Liao H-M, Chao Y-L, Huang A-L, Cheng M-C, Chen Y-J, Lee K-F, et al. Identification and characterization of three inherited genomic copy number variations associated with familial schizophrenia. Schizophr Res. 2012;139(1–3):229–36.PubMedCrossRefGoogle Scholar
  17. Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, et al. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene. 1997;15(18):2145–50.PubMedCrossRefGoogle Scholar
  18. Park D, Tosello-Trampont A-C, Elliott MR, Lu M, Haney LB, Ma Z, et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007;450(7168):430–4.PubMedCrossRefGoogle Scholar
  19. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet Cell Genet. 1997;79(1–2):103–8.PubMedCrossRefGoogle Scholar
  20. Sigoillot SM, Iyer K, Binda F, González-Calvo I, Talleur M, Vodjdani G, et al. The secreted protein c1ql1 and its receptor BAI3 control the synaptic connectivity of excitatory inputs converging on cerebellar purkinje cells. Cell Rep. 2015;10(5):820–32.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Queensland Brain Institute – University of QueenslandBrisbaneAustralia