Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ADGRB3

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101539

Synonyms

Historical Background

The adhesion G protein–coupled receptor (GPCR) BAI subfamily was uncovered in 1997 by Dr. Tokino’s laboratory. They first discovered the hBAI1 gene as a target gene for the p53 tumor suppressor in a cDNA library of fetal human brain (Nishimori et al. 1997). They subsequently identified two homologous genes: hBAI2 and hBAI3 which are not regulated by p53 (Shiratsuchi et al. 1997). This adhesion GPCR subfamily was named human brain-specific Angiogenesis inhibitor because of the capacity of BAI1 to inhibit neovascularization in a rat cornea model, and its predominant expression in the human brain. In 2015, a new nomenclature has been proposed for all the adhesion GPCRs by the Adhesion GPCR Consortium and the International Union of Basic and Clinical Pharmacology Committee. For the BAI subfamily, this new nomenclature is: ADhesion G protein–coupled Receptor B or ADGRB1–3 (Hamann et...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Queensland Brain Institute – University of QueenslandBrisbaneAustralia