S100A6 belongs to the S100 family of Ca2+-binding proteins of the EF-hand type (reviewed in Donato et al. 2013). As a member of the A group of S100 proteins, human S100A6 gene maps to chromosome 1q21. S100A6 is expressed as an 89-amino-acid protein in mouse and rat and a 90-amino-acid protein in human and rabbit. Two chicken isoforms, A (92 amino acids) and B (91 amino acids), probably result from alternative mRNA splicing. S100A6 from all these sources differs in only a few amino acids and in the length of the carboxy terminus. The S100A6 gene was initially identified in growth-arrested rodent fibroblasts stimulated with serum and suggested to have a role in cell-cycle progression as inferred by its upregulation in several tumors (reviewed in Leśniak et al. 2009). S100A6 was found to interact with...
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