Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Rosario DonatoEmail author
  • Guglielmo Sorci
  • Ileana Giambanco
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101531


Historical Background

S100A6 belongs to the S100 family of Ca2+-binding proteins of the EF-hand type (reviewed in Donato et al. 2013). As a member of the A group of S100 proteins, human S100A6 gene maps to chromosome 1q21. S100A6 is expressed as an 89-amino-acid protein in mouse and rat and a 90-amino-acid protein in human and rabbit. Two chicken isoforms, A (92 amino acids) and B (91 amino acids), probably result from alternative mRNA splicing. S100A6 from all these sources differs in only a few amino acids and in the length of the carboxy terminus. The S100A6 gene was initially identified in growth-arrested rodent fibroblasts stimulated with serum and suggested to have a role in cell-cycle progression as inferred by its upregulation in several tumors (reviewed in Leśniak et al. 2009). S100A6 was found to interact with...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Rosario Donato
    • 1
    Email author
  • Guglielmo Sorci
    • 2
    • 3
  • Ileana Giambanco
    • 1
  1. 1.Department of Experimental Medicine, Centro Universitario per la Ricerca sulla Genomica Funzionale, Instituto Interuniversitario di MiologiaPerugia Medical School, University of PerugiaPerugiaItaly
  2. 2.Department of Experimental Medicine, Perugia Medical SchoolUniversity of PerugiaPerugiaItaly
  3. 3.Istituto Interuniversitario di Miologia (Interuniversity Institute for Myology), Perugia Medical SchoolUniversity of PerugiaPerugiaItaly