Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Igor PrudovskyEmail author
  • Thallapuranam Krishnaswamy Suresh Kumar
  • Rosario Donato
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101530


Historical Background

S100A13 belonging to S100 protein family was discovered in 1996 in the laboratory of Claus W. Heizmann (Wicki et al. 1996). The S100A13 gene is localized on human chromosome 1q21 in the cluster of genes coding for other S100 proteins (Ridinger et al. 1998). High levels of S100A13 expression were reported for skeletal muscle, heart, kidney, ovary, small intestine, and pancreas (Ridinger et al. 2000).

S100A13 and Nonclassical Protein Export (FGF1, IL1α, Prothymosin)

Similar to other members of S100 family, S100A13 is secreted despite the absence in its structure of a signal peptide required for translocation into the lumen of the endoplasmic reticulum (ER) (Landriscina et al. 2001). NIH3T3 cells transfected with S100A13 spontaneously release it through an unconventional ER-Golgi independent pathway (Landriscina et al. 2001). S100A13 has been detected in a brain-derived...

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  1. Arnesano F, Banci L, Bertini I, Fantoni A, Tenori L, Viezzoli MS. Structural interplay between calcium(II) and copper(II) binding to S100A13 protein. Angew Chem Int Ed Engl. 2005;44(39):6341–4.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Dinets A, Pernemalm M, Kjellin H, Sviatoha V, Sofiadis A, Juhlin CC, et al. Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions. PLoS One. 2015;10(5):e0126472.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Halder SK, Matsunaga H, Ueda H. Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns. J Neurochem. 2012;123(2):262–75.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Huang CT, Chen CH. Identification of gene transcripts in rat frontal cortex that are regulated by repeated electroconvulsive seizure treatment. Neuropsychobiology. 2008;58(3–4):171–7.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Imai FL, Nagata K, Yonezawa N, Nakano M, Tanokura M. Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64(Pt 2):70–6.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Inoue O, Hokamura K, Shirai T, Osada M, Tsukiji N, Hatakeyama K, et al. Vascular smooth muscle cells stimulate platelets and facilitate thrombus formation through platelet CLEC-2: implications in atherothrombosis. PLoS One. 2015;10(9):e0139357.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Lambros MP, Parsa C, Mulamalla H, Orlando R, Lau B, Huang Y, et al. Identifying cell and molecular stress after radiation in a three-dimensional (3-D) model of oral mucositis. Biochem Biophys Res Commun. 2011;405(1):102–6.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Landriscina M, Soldi R, Bagala C, Micucci I, Bellum S, Tarantini F, et al. S100A13 participates in the release of fibroblast growth factor 1 in response to heat shock in vitro. J Biol Chem. 2001;276(25):22544–52.PubMedPubMedCentralCrossRefGoogle Scholar
  9. Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, et al. S100A13 mediates the copper-dependent stress-induced release of IL-1{alpha} from both human U937 and murine NIH 3 T3 cells. J Cell Sci. 2003;116(Pt 13):2687–96.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Massi D, Landriscina M, Piscazzi A, Cosci E, Kirov A, Paglierani M, et al. S100A13 is a new angiogenic marker in human melanoma. Mod Pathol. 2010;23(6):804–13.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Matsunaga H, Ueda H. Evidence for serum-deprivation-induced co-release of FGF-1 and S100A13 from astrocytes. Neurochem Int. 2006;49(3):294–303.PubMedPubMedCentralCrossRefGoogle Scholar
  12. McLaughlin S. The electrostatic properties of membranes. Annu Rev Biophys Biophys Chem. 1989;18:113–36.PubMedPubMedCentralCrossRefGoogle Scholar
  13. Prudovsky I, Mandinova A, Soldi R, Bagala C, Graziani I, Landriscina M, et al. The non-classical export routes: FGF1 and IL-1alpha point the way. J Cell Sci. 2003;116(Pt 24):4871–81.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Rajalingam D, Kumar TK, Yu C. The C2A domain of synaptotagmin exhibits a high binding affinity for copper: implications in the formation of the multiprotein FGF release complex. Biochemistry. 2005;44(44):14431–42.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Rani SG, Sepuru KM, Yu C. Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE). Biochim Biophys Acta. 2014;1844(9):1718–28.PubMedPubMedCentralCrossRefGoogle Scholar
  16. Ridinger K, Ilg EC, Niggli FK, Heizmann CW, Schafer BW. Clustered organization of S100 genes in human and mouse. Biochim Biophys Acta. 1998;1448(2):254–63.PubMedPubMedCentralCrossRefGoogle Scholar
  17. Ridinger K, Schafer BW, Durussel I, Cox JA, Heizmann CW. S100A13. Biochemical characterization and subcellular localization in different cell lines. J Biol Chem. 2000;275(12):8686–94.PubMedPubMedCentralCrossRefGoogle Scholar
  18. Sivaraja V, Kumar TK, Prudovsky I, Yu C. Three-dimensional solution structure of a unique S100 protein. Biochem Biophys Res Commun. 2005;335(4):1140–8.PubMedPubMedCentralCrossRefGoogle Scholar
  19. Wicki R, Schafer BW, Erne P, Heizmann CW. Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family. Biochem Biophys Res Commun. 1996;227(2):594–9.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Igor Prudovsky
    • 1
    Email author
  • Thallapuranam Krishnaswamy Suresh Kumar
    • 2
  • Rosario Donato
    • 3
  1. 1.Maine Medical Center Research InstituteScarboroughUSA
  2. 2.Department of Chemistry and BiochemistryUniversity of Arkansas, Chemistry BldgFayettevilleUSA
  3. 3.Department of Experimental Medicine, Centro Universitario per la Ricerca sulla Genomica FunzionaleIstituto Interuniversitario di Miologia, Perugia Medical School, University of PerugiaPerugiaItaly