Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

S100a13

  • Igor Prudovsky
  • Thallapuranam Krishnaswamy Suresh Kumar
  • Rosario Donato
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101530

Synonyms

Historical Background

S100A13 belonging to S100 protein family was discovered in 1996 in the laboratory of Claus W. Heizmann (Wicki et al. 1996). The S100A13 gene is localized on human chromosome 1q21 in the cluster of genes coding for other S100 proteins (Ridinger et al. 1998). High levels of S100A13 expression were reported for skeletal muscle, heart, kidney, ovary, small intestine, and pancreas (Ridinger et al. 2000).

S100A13 and Nonclassical Protein Export (FGF1, IL1α, Prothymosin)

Similar to other members of S100 family, S100A13 is secreted despite the absence in its structure of a signal peptide required for translocation into the lumen of the endoplasmic reticulum (ER) (Landriscina et al. 2001). NIH3T3 cells transfected with S100A13 spontaneously release it through an unconventional ER-Golgi independent pathway (Landriscina et al. 2001). S100A13 has been detected in a brain-derived...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Igor Prudovsky
    • 1
  • Thallapuranam Krishnaswamy Suresh Kumar
    • 2
  • Rosario Donato
    • 3
  1. 1.Maine Medical Center Research InstituteScarboroughUSA
  2. 2.Department of Chemistry and BiochemistryUniversity of Arkansas, Chemistry BldgFayettevilleUSA
  3. 3.Department of Experimental Medicine, Centro Universitario per la Ricerca sulla Genomica FunzionaleIstituto Interuniversitario di Miologia, Perugia Medical School, University of PerugiaPerugiaItaly