Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Ruchi KumariEmail author
  • Parmjit Jat
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101529


Historical Background

B-MYB is a member of the Myeloblastosis transcription factor (TF) family which is present in all vertebrates. The other members of the family are A-MYB and c-MYB. c-MYB was the first one to be discovered as a homologue of the v-MYB oncogene carried by two different avian leukemia viruses, Avian Myeloblastosis Virus (AMV) and E26 (Fig. 1) which cause acute myeloblastic leukemia and can also transform immature hematopoietic cells in culture.
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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Neurodegenerative DiseaseInstitute of Neurology, University College LondonLondonUK