Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ATP-Binding Cassette Subfamily A Member 2

  • Soheila RahgozarEmail author
  • Narges Aberuyi
  • Hadi Moafi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101528


Historical Background

ATP-binding cassette (ABC) transporters are integral membrane proteins that cross the intracellular (organelles) and cytoplasmic membranes and are involved directly in the transport of substrates against a concentration gradient using ATP hydrolysis. The superfamily of human ABC transporters comprises 49 members and has a wide variety of functions. This family is divided into seven subfamilies from A to G, with the ABC “A” subfamily containing 13 members, such as ABCA1, ABCA2, and ABCA7, which transport sterols. The second member of the ABCA subfamily is named ABCA2. It is expressed at high levels in the white matter of the brain (Halene et al. 2016), as well as oligodendrocytes, schwann cells, excitatory and inhibitory neurons (Mack et al. 2012), brain capillary endothelial cells (Wolf et al. 2012), and glial cells...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiologyUniversity of IsfahanIsfahanIran
  2. 2.University of IsfahanIsfahanIran
  3. 3.University of British ColumbiaVancouverCanada