Historical Background
The active transport of sodium in epithelial tissue has been stated since 1950s (Leaf et al. 1958). In 1962, scientists found that the movement of Na+ from the liquid of lumen side into epithelial cell was not in the manner of free diffusion, but was possibly driven by electrical forces through the interaction with a saturable permease on the plasma membrane (Frazier 1962; Frazier et al. 1962; Park and Fanestil 1980). In 1970s, this permease was found to be the target of amiloride, the specific blocker of epithelial Na+ channel (ENaC), and active as a channel rather than a carrier (Lindemann and Van Driessche 1977; Park and Fanestil 1980). Epithelial Na+channel (ENaC) was characterized as to be...
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Barbry P, Champe M, Chassande O, Munemitsu S, Champigny G, Lingueglia E, et al. Human kidney amiloride-binding protein: cDNA structure and functional expression. Proc Natl Acad Sci U S A. 1990;87:7347–51.
Benos DJ, Saccomani G, Sariban-Sohraby S. The epithelial sodium channel. Subunit number and location of the amiloride binding site. J Biol Chem. 1987;262:10613–8.
Canessa CM, Horisberger JD, Rossier BC. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 1993;361:467–70. https://doi.org/10.1038/361467a0.
Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, et al. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994;367:463–7. https://doi.org/10.1038/367463a0.
Frazier HS. The electrical potential profile of the isolated toad bladder. J Gen Physiol. 1962;45:515–28.
Frazier HS, Dempsey EF, Leaf A. Movement of sodium across the mucosal surface of the isolated toad bladder and its modification by vasopressin. J Gen Physiol. 1962;45:529–43.
Hanukoglu I, Hanukoglu A. Epithelial sodium channel (ENaC) family: phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene. 2016;579:95–132. https://doi.org/10.1016/j.gene.2015.12.061.
Ji HL, Zhao RZ, Chen ZX, Shetty S, Idell S, Matalon S. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Phys Lung Cell Mol Phys. 2012;303:L1013–26. https://doi.org/10.1152/ajplung.00206.2012.
Leaf A, Anderson J, Page LB. Active sodium transport by the isolated toad bladder. J Gen Physiol. 1958;41:657–68.
Lindemann B, Van Driessche W. Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover. Science. 1977;195:292–4.
Lingueglia E, Voilley N, Waldmann R, Lazdunski M, Barbry P. Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 1993;318:95–9.
Pao AC. There and back again: insulin, ENaC, and the cortical collecting duct. Phys Rep. 2016;4(10):e12809. https://doi.org/10.14814/phy2.12809.
Park CS, Fanestil DD. Covalent modification and inhibition of an epithelial sodium channel by tyrosine-reactive reagents. Am J Phys. 1980;239:F299–306.
Rossier BC, Pradervand S, Schild L, Hummler E. Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol. 2002;64:877–97. https://doi.org/10.1146/annurev.physiol.64.082101.143243.
Rossier BC, Baker ME, Studer RA. Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited. Physiol Rev. 2015;95:297–340. https://doi.org/10.1152/physrev.00011.2014.
Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012;47:349–59. https://doi.org/10.3109/10409238.2012.678285.
Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M. Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem. 1995;270:27411–4.
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Liu, Y., Ji, HL. (2018). ENaC. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101527
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