Historical Background
Phosphatidylinositol kinase activity was initially defined by Mitchell and colleagues as one that could transfer the γ-phosphoryl group of 32P-labeled ATP to phosphatidylinositol in membrane fractions derived from tissues (Michell et al. 1967). Two decades later, studies involving the use of cell and tissue extracts revealed that phosphatidylinositol kinase activity could be separated into three distinct types based on sensitivity to inhibitors and migration in a sucrose gradient (Whitman et al. 1987). These were described as the type I, II, and III phosphatidylinositol kinases. The type I enzyme was later found to phosphorylate the D3 position of the myo-inositol moiety of phosphatidylinositol and is now referred to as phosphatidylinositol 3-kinase (PI3K). The type II and III enzymes phosphorylate the D4 position but exhibit different biochemical characteristics such as sensitivities to inhibitors and migration in a sucrose gradient. The...
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Alli-Balogun, G., Minogue, S. (2018). Phosphatidylinositol 4-Kinase (PI4K2B). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101524
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101524
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