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p38 Gamma MAPK

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

Synonyms

ERK6 (extracellular signal-regulated kinase 6); MAPK12; p38γ; p38γ MAPK (p38γ mitogen-activated protein kinase); SAPK3 (Stress-activated protein kinase 3)

Historical Background

p38 mitogen-activated protein kinases (p38 MAPKs) are a group of serine/threonine protein kinases, which together with extracellular signal-regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs) MAPKs convert upstream signals into cellular responses. Four mammalian p38 MAPK family proteins (α, β, γ, and δ) are encoded by four separate genes and play an overlapping, distinct, and even opposite role in regulating cell growth, cell death, and differentiation (Ono and Han 2000; Kumar et al. 2003; Cuenda and Rousseau 2007; Loesch and Chen 2008). Among 15 classical and nonclassical MAPKs, p38γ is an only MAPK with its C-terminus containing an unique PDZ-binding motif (Lechner et al. 1996; Li et al. 1996; Mertens et al. 1996; Cargnello and Roux 2011). p38γ signals downstream of MAPK kinase 6 (MKK6) and...

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Acknowledgements

The work in Chen lab was supported by grants from National Institutes of Health, Department of Veterans Affair (VA), and Department of Defense (DoD). We would like to acknowledge the former lab members Drs. Jung Tang, Rocky Pramanik, Song-Wang Hou, Mathew Loesch, Adrienne Lepp, Padmanaban S. Suresh, Shao Ma, and Ning Yin for their contributions.

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  1. Department of Pharmacology and Toxicology, Zablocki Department of Veterans Affairs Medical Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA

    Xiao-Mei Qi, Fang Wang & Guan Chen

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  1. Xiao-Mei Qi
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  2. Fang Wang
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Correspondence to Guan Chen .

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  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Qi, XM., Wang, F., Chen, G. (2018). p38 Gamma MAPK. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101521

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