Matriptase (ST14, Suppressor of Tumorigenicity 14 Protein)
Matriptase is a type II transmembrane serine protease expressed in most types of epithelia (Oberst et al. 2003a). Matriptase was discovered in 1993 as a novel matrix degrading enzyme purified from human breast cancer cells (Shi et al. 1993). Since then, five independent groups have cloned the matriptase cDNA, and the protease has been published under the names membrane-type serine protease 1 (MT-SP1), tumor-associated differentially expressed gene-15 (TADG-15), epithin (in mouse), and SNC19 (Kim et al. 1999; Takeuchi et al. 1999; Cao et al. 2001; Tanimoto et al. 2001). The matriptase gene was given the name suppression of tumorgenecity 14 (ST14) (Zhang et al. 1998).
Matriptase expression studies have been performed in adult human tissue by mRNA, and protein analysis and matriptase expression has been found...
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