Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Christiane KirchhoffEmail author
  • Heike Cappallo-Obermann
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101510


Historical Background

ADGRG2 was initially identified in a recombinant cDNA library constructed from a human epididymis (Osterhoff et al. 1997). It was highly represented in this library (approximately 0.01% of clones), indicating that the corresponding mRNA was enriched in this tissue. Differential screening employing polyA+RNA from various control tissues, i.e., human testis, liver, and brain, further suggested prevalent expression in the epididymis. Hence, it was named HE6 for Human Epididymis cDNA 6. The nearly 5 kb “full length” cDNA comprised one long open reading frame predicting an approximately 1000-residue polypeptide chain. Protein structure prediction revealed a multipass transmembrane protein with seven hydrophobic...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Andrology, Clinic for Dermatology and VenereologyUniversity Hospital Hamburg-EppendorfHamburgGermany