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Encyclopedia of Signaling Molecules pp 2888–2893Cite as

Lyn

  • Reference work entry
  • First Online:

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Synonyms

Hck-2; JTK8; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

Historical Background

Tyrosine kinases play a significant role in different cellular processes such as cell growth, apoptosis, and migration (Ingley 2012; Manning et al. 2002). Also tyrosine kinases regulate many inflammatory modulators that regulate immune response (Ingley 2012; Manning et al. 2002). Src family kinases (SFKs) include different tyrosine kinases like Src, Lyn, Yes, Fyn, Blk, Yrk, Fgr, Hck, and Lck. These intracellular membrane-associated non-receptor tyrosine kinases control different biological processes (Ingley et al. 2007; Parsons and Parsons 2004). The overexpression and higher activity of SFKs enhance different types of cancer cell growth, and various studies demonstrated the involvement of SFKs in various tumor progression and metastasis (Resh 1999; Boggon and Eck 2004; Selvakumar et al. 2007). Lyn is a member of the SFK family; solid tumors including colon cancer, prostate cancer,...

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Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

    Ponniah Selvakumar

  2. Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, SK, Canada

    Ponniah Selvakumar

  3. Department of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA

    Sai Kundur, Hung Nguyen, Lloyd McKee, Clairissa Cruz, Ponniah Selvakumar & Ashakumary Lakshmikuttyamma

Authors
  1. Sai Kundur
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  2. Hung Nguyen
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  3. Lloyd McKee
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  4. Clairissa Cruz
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  5. Ponniah Selvakumar
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  6. Ashakumary Lakshmikuttyamma
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Corresponding author

Correspondence to Ashakumary Lakshmikuttyamma .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Kundur, S., Nguyen, H., McKee, L., Cruz, C., Selvakumar, P., Lakshmikuttyamma, A. (2018). Lyn. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101499

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