Historical Background Putative
Gamma syntrophins were discovered by a team of scientists led by Giulio Pilusoin in the year 2000. They found that human neuronal cell contains two novel proteins which have domain organization similar to already discovered syntrophins. They named these two proteins as gamma-1-syntrophin (SNTG1) and gamma-2-syntrophin (SNTG2). Syntrophins are adapter proteins which include other three known homologous isoforms alpha-1-syntrophin (SNTA1), beta-1-syntrophin (SNTB1), and beta-2-syntrophin (SNTB2) (Froehner et al. 1997). Syntrophins are usually found associated with dystrophin family of proteins and got their name from a Greek word “syntrophos” meaning “companion” or “associate” (Froehner et al. 1997). Gamma-1-syntrophin protein is encoded by SNTG1 gene which is located on chromosome 1 in mouse and on chromosome 8 in humans. Human SNTG1 gene is composed of 19 exons and codes for a brain-specific protein of 517...
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