Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Adenomatous Polyposis Coli

  • Jonathan AlexanderEmail author
  • Antonella PironeEmail author
  • Michele Jacob
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101487


Historical Context

“You are old, Father William,” the young surgeon said,

“And your colon from polyps is free.

Yet most of your siblings are known to be dead –

A really bad family tree”

“In my youth,” Father William replied with a grin,

“I was told that a gene had mutated,

That all who carried this dominant gene

To polyps and cancer were fated.”

Cuthbert Dukes, from a speech entitled “

Familial Intestinal Polyps” delivered to the Royal College of Surgeons of England March 25th, 1952

Familial adenomatous polyposis (FAP) was first thought to be identified by H. Luschka in 1861, who described a colon containing thousands of polyps. The hereditary nature of this disease came into focus with a second case report in 1882 by Cripps who identified polyposis within two...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of NeuroscienceTufts University School of MedicineBostonUSA