Germinoma; Mediastinal; Primary mediastinal seminoma; Seminoma of the mediastinum
Seminoma of the mediastinum is a germ cell tumor (GCT) composed of uniform cells of a single type. These cells measure 15–25 μm and have glycogen-rich clear or slightly eosinophilic cytoplasm and regular vesicular nuclei. They are arranged into lobular nests surrounded by fibrous septa filled with lymphocytes. Microscopically it is indistinguishable from testicular seminoma or ovarian dysgerminoma.
Like all other germ cell tumors of the mediastinum, seminomas are rare tumors. Seminoma is the most common mediastinal malignant GCT, accounting for approximately one third of all tumors in this group.
Like testicular seminomas, the mediastinal equivalents develop only in postpubertal males. Mediastinal seminoma has not been described in boys younger than 10 years. The mean age of patients at the time of diagnosis is 47 years.
With a few exceptions, almost...
References and Further Reading
- Stang, A., Trabert, & Wentzensen N, et al. (1973–2007). Gonadal and extragonadal germ cell tumors in the United States. International Journal of Andrology, 35, 616–625.Google Scholar