Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Seminoma, Mediastinal

  • Ivan DamjanovEmail author
  • Ivana Mrklic
Reference work entry


Germinoma; Mediastinal; Primary mediastinal seminoma; Seminoma of the mediastinum


Seminoma of the mediastinum is a germ cell tumor (GCT) composed of uniform cells of a single type. These cells measure 15–25 μm and have glycogen-rich clear or slightly eosinophilic cytoplasm and regular vesicular nuclei. They are arranged into lobular nests surrounded by fibrous septa filled with lymphocytes. Microscopically it is indistinguishable from testicular seminoma or ovarian dysgerminoma.

Clinical Features

  • Incidence

    Like all other germ cell tumors of the mediastinum, seminomas are rare tumors. Seminoma is the most common mediastinal malignant GCT, accounting for approximately one third of all tumors in this group.

  • Age

    Like testicular seminomas, the mediastinal equivalents develop only in postpubertal males. Mediastinal seminoma has not been described in boys younger than 10 years. The mean age of patients at the time of diagnosis is 47 years.

  • Sex

    With a few exceptions, almost...

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References and Further Reading

  1. Moran, C. A., Suster, S., Przygodzki, R. M., et al. (1997). Primary germ cell tumors of the mediastinum. II. Mediastinal seminomas – A clinicopathologic and immunohistochemical study of 120 cases. Cancer, 80, 691–698.CrossRefPubMedGoogle Scholar
  2. Stang, A., Trabert, & Wentzensen N, et al. (1973–2007). Gonadal and extragonadal germ cell tumors in the United States. International Journal of Andrology, 35, 616–625.Google Scholar
  3. Weidner, N. (1999). Germ-cell tumors of the mediastinum. Seminars in Diagnostic Pathology, 16, 42–50.PubMedGoogle Scholar
  4. Weissferdt, A., Kalhor, N., & Moran, C. A. (2014). Combined thymoma-thymic seminoma. Report of 2 cases of a heretofore unreported association. Human Pathology, 45, 2168–2172.CrossRefPubMedGoogle Scholar
  5. Williamson, S. R., & Ulbright, T. M. (2014). Germ cell tumors of the mediastinum. In A. M. Marchevsky & M. R. Wick (Eds.), Pathology of the mediastinum (pp. 146–168). New York: Cambridge University Press.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Kansas School of MedicineKansas CityUSA
  2. 2.Institute of PathologyUniversity of SplitSplitCroatia