Synonyms
Extraosseous osteogenic sarcoma; Extraosseous osteosarcoma
Definition
Extraskeletal osteosarcoma is a malignant osteoid-producing soft tissue neoplasm that by definition is unattached to the bone or periosteum. Contrary to osteosarcoma of the bone which mainly affects adolescents and young adults, extraskeletal osteosarcoma is a disease of middle-aged and older adults which infrequently occurs in patients under the age of 40. Extraskeletal osteosarcoma is a rare malignancy that accounts for only 1–2% of all soft tissue sarcomas and for 2–4% of all osteosarcomas. It most commonly arises in the soft tissues of the lower extremities, especially the thigh but also in the buttocks, shoulder girdle, trunk, and retroperitoneum. Primary mediastinal extraskeletal osteosarcomas have been reported as isolated case reports; to date, less than ten cases have been published in the English literature (Hishida et al. 2009). Several hypotheses as to the histogenesis of these tumors exist...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Catanese, J., Dutcher, J. P., Dorfman, H. D., Andres, D. F., & Wiernik, P. H. (1988). Mediastinal osteosarcoma with extension to lungs in a patient treated for Hodgkin’s disease. Cancer, 62, 2252–2257.
Fanburg-Smith, J. C., Bratthauer, G. L., & Miettinen, M. (1999). Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: A study of 28 cases. Human Pathology, 30, 32–38.
Guillou, L., & Aurias, A. (2010). Soft tissue sarcomas with complex genomic profiles. Virchows Archives, 456, 201–217.
Hishida, T., Yoshida, J., Nishimura, M., Ishii, G., Nakao, M., & Nagai, K. (2009). Extraskeletal osteosarcoma arising in anterior mediastinum: Brief report with a review of the literature. Journal of Thoracic Oncology, 4, 927–929.
Lee, J. S., Fetsch, J. F., Wasdhal, D. A., Lee, B. P., Pritchard, D. J., & Nascimento, A. G. (1995). A review of 40 patients with extraskeletal osteosarcoma. Cancer, 76, 2253–2259.
McCarter, M. D., Lewis, J. J., Antonescu, C. R., & Brennan, M. F. (2000). Extraskeletal osteosarcoma: Analysis of outcome of a rare neoplasm. Sarcoma, 4, 119–123.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this entry
Cite this entry
Weissferdt, A., Moran, C.A. (2018). Mediastinal Extraskeletal Osteosarcoma. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_43
Download citation
DOI: https://doi.org/10.1007/978-3-319-66796-6_43
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-66795-9
Online ISBN: 978-3-319-66796-6
eBook Packages: MedicineReference Module Medicine