Rosai-Dorfman Disease, Pleural
Destombes-Rosai-Dorfman; DRDD; RDD; SHML; Sinus histiocytosis with massive lymphadenopathy
Rosai-Dorfman disease (RDD) is a polyclonal, benign proliferation of macrophages with a histologically reactive morphology causing painless, chronic, massive lymphadenopathy and occasional extranodal manifestations. In 1992, a landmark study of RDD reported detection of HHV-6 genome by in situ hybridization in 7 out of 9 RDD patients evaluated and EBV genome in a single patient (Levine et al. 1992). Viral infections, namely, HHV-6, may be the underlying cause of RDD.
Rare; data from a disease registry of 423 patients is available from a 1990 report (Foucar et al. 1990).
May be slightly more common in male patients overall (58% of patients); however, 6 of 9 patients with...
References and Further Reading
- Filipovich, M. B. J. a. A. H. (2012). Hoffman: hematology: Basic principles and practice (6th ed.). 699–700.Google Scholar