Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Rheumatoid Pleuritis

  • Melanie BoisEmail author
Reference work entry


Rheumatoid lung disease; Rheumatoid nodules; Rheumatoid pleural effusion; Rheumatoid pleurisy


Pleuropulmonary manifestations of rheumatoid arthritis (RA) include interstitial lung disease, organizing pneumonia, small and large airway inflammation, pleural nodules, and pleural effusions (Amital et al. 2011; Anaya et al. 1995; Schneider et al. 2012). Of the aforementioned, those processes that involve the pleura are the most common thoracic manifestations of RA (Anaya et al. 1995; Highland and Heffner 2004; Schneider et al. 2012; Shannon and Gale 1992).

Pleuritis occurs in patients with long-standing rheumatoid arthritis and has a tendency to herald an exacerbation of arthritis (Amital et al. 2011; Highland and Heffner 2004). Genetic predisposition to pleural involvement in RA has been linked to HLA-B8 and Dw3 (Amital et al. 2011). While RA is more common in women, pleural involvement of RA is more commonly found in men (Amital et al. 2011; Anaya et al. 1995;...

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References and Further Reading

  1. Amital, A., Shitrit, D., & Adir, Y. (2011). The lung in rheumatoid arthritis. Presse Médicale, 40, e53–e70.CrossRefGoogle Scholar
  2. Anaya, J. M., Diethelm, L., Ortiz, L. A., Gutierrez, M., et al. (1995). Pulmonary involvement in rheumatoid arthritis. Seminars in Arthritis and Rheumatism, 24(4), 242–254.CrossRefPubMedGoogle Scholar
  3. Highland, K. B., & Heffner, J. E. (2004). Pleural effusions in interstitial lung disease. Current Opinion in Pulmonary Medicine, 10, 390–396.CrossRefPubMedGoogle Scholar
  4. Schneider, F., Gruden, J., Tazelaar, H. D., & Leslie, K. O. (2012). Pleuropulmonary pathology in patients with rheumatic disease. Archives of Pathology & Laboratory Medicine, 136(10), 1242–1252.CrossRefGoogle Scholar
  5. Shannon, T. M., & Gale, M. E. (1992). Noncardiac manifestations of rheumatoid arthritis in the thorax. Journal of Thoracic Imaging, 7(2), 19–29.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mayo ClinicRochesterUSA