Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Primary Squamous Cell Carcinoma, Pleural

  • Sara FaizEmail author
  • Timothy Craig Allen
Reference work entry


No synonyms have been described for this entity.


Carcinoma arising from squamous epithelial cells, morphologically characterized by proliferation of atypical, often pleomorphic squamous cells, and graded as well, moderately, or poorly differentiated and well-differentiated carcinomas are usually associated with keratin production and presence of intercellular bridges between adjacent cells; subtypes include basaloid, clear cell type, papillary, and small cell nonkeratinizing.

Clinical Features

  • Incidence

    Primary pleural squamous cell carcinoma (SCC) is a very rare pleural malignancy which has seldom been reported. Cases of squamous cell carcinoma arising from the pleura in patients with a chronically draining empyema cavity have rarely been reported. Chronic pleural inflammation may therefore be one of the causes of primary pleural SCC.

  • Age

    Malignant pleural tumors are usually seen in older adults.

  • Sex

    Primary SCC is mostly reported in males.

  • Site

    It is unknown how...

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References and Further Reading

  1. Cardillo, G., Facciolo, F., Cavazzana, A. O., Capece, G., Gasparri, R., & Martelli, M. (2000). Localized (solitary) fibrous tumors of the pleura: An analysis of 55 patients. The Annals of Thoracic Surgery, 70(6), 1808–1812.CrossRefPubMedGoogle Scholar
  2. Franke, M., Chung, H. D., & Johnson, F. E. (2010). Squamous cell carcinoma arising from the pleura after pneumonectomy for squamous cell carcinoma of the lung. American Journal of Surgery, 199(4), e34–e35.CrossRefPubMedGoogle Scholar
  3. Lin, X. M., Chi, C., Chen, J., Liu, Y., Li, P., & Yang, Y. (2013). Primary pleural squamous cell carcinoma misdiagnosed as localized mesothelioma: A case report and review of the literature. Journal of Cardiothoracic Surgery, 8, 50.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Magdeleinat, P., Alifano, M., Petino, A., Le Rochais, J. P., Dulmet, E., Galateau, F., et al. (2002). Solitary fibrous tumors of the pleura: Clinical characteristics, surgical treatment and outcome. European Journal of Cardio-Thoracic Surgery: Official Journal of the European Association for Cardio-Thoracic Surgery, 21(6), 1087–1093.CrossRefGoogle Scholar
  5. Ordonez, N. G. (2005). Mesothelioma with clear cell features: An ultrastructural and immunohistochemical study of 20 cases. Human Pathology, 36(5), 465–473.CrossRefPubMedGoogle Scholar
  6. Ordonez, N. G. (2007). What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update. Human Pathology, 38(1), 1–16.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University of Texas Medical Branch at GalvestonGalvestonUSA
  2. 2.Department of PathologyThe University of Mississippi Medical School, The University of Mississippi Medical CenterJacksonUSA