Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Localized Malignant Mesothelioma, Pleural

  • Riyam ZreikEmail author
  • Timothy Craig Allen
Reference work entry


Localized malignant pleural mesothelioma; Localized mesothelioma


Localized malignant mesothelioma was recognized as a distinct entity and added to the World Health Organization (WHO) classification of tumors in 2004 and is defined by the WHO as a rare localized malignant neoplasm, “without gross or microscopic evidence of diffuse pleural spread, but with the microscopic, histochemical, immunohistochemical and ultrastructural features of diffuse malignant mesothelioma” (Churg et al. 2004). Localized malignant mesothelioma of the pleura was first described in 1994 by Crotty et al., and since 2012, only 53 cases have been reported in the literature (Nakano et al. 2012). These malignant tumors, though localized, are classified as T3N0M0 (stage III) based on the AJCC 2010 cancer staging classification system.

The largest series of localized malignant mesotheliomas to date was published by Allen et al. in 2005 who reported 23 patients, of which 21 patients had follow-up...

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References and Further Reading

  1. Allen, T. C., Cagle, P. T., Churg, A. M., Colby, T. V., Gibbs, A. R., Hammar, S. P., & Wick, M. R. (2005). Localized malignant mesothelioma. The American Journal of Surgical Pathology, 29(7), 866–873.CrossRefPubMedGoogle Scholar
  2. Churg, A., Roggli, V., Galateau-Salle, F., Cagle, P. T., Gibbs, A. R., Hasleton, P. S., & Travis, W. D. (2004). Mesothelioma. In W. D. Travis, E. Brambilla, H. K. Müller-Hermelink, & C. C. Harris (Eds.), World Health Organization classification of tumours: pathology and genetics of tumours of the lung, pleura, thymus and heart (pp. 128–136). Lyon: IARC Press.Google Scholar
  3. Gelvez-Zapata, S. M., Gaffney, G., Scarci, M., & Coonar, A. S. (2013). What is the survival after surgery for localized malignant pleural mesothelioma? Interactive Cardiovascular and Thoracic Surgery, 16, 533–537. doi:10.1093/icvts/ivs542.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Husain, A. N., Colby, T., Ordonez, N., Krausz, T., Attanoos, R., Beasley, M. B., . . ., Wick, M. (2013). Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the international mesothelioma interest group. Archives of Pathology & Laboratory Medicine, 137, 647–667. doi:10.5858/arpa.2012-0214-OA.CrossRefGoogle Scholar
  5. Nakano, T., Hamanaka, R., Oiwa, K., Nakazato, K., Masuda, R., & Iwazaki, M. (2012). Localized malignant pleural mesothelioma. General Thoracic and Cardiovascular Surgery, 60, 468–474. doi:10.1007/s11748-012-0025-3.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyScott & White Healthcare and Texas A&M Health Science Center College of MedicineTempleUSA
  2. 2.Department of PathologyThe University of Texas Medical Branch301 University Boulevard GalvestonUSA