Synonyms
Obliteration of pleural cavity; Pleurosclerosis; Scarification of pleura
Definition
Pleurodesis, from the Greek pleura and desis (binding together), is the artificial production of adhesions between the parietal and visceral pleura for the treatment of a persistent pneumothorax or severe pleural effusion, and mesothelioma, according to the 29th edition of Dorland’s Illustrated Medical Dictionary.
Pleurodesis has been performed since the beginning of the twentieth century, and various agents have been used. However, the search for the ideal sclerosing agent continues.
Among the chemicals that have been used to produce pleurodesis are the following: talc, Corynebacterium parvum, macrolides, quinolones, doxycycline, tetracycline (TCN), and bleomycin. Recently, biological mediators of inflammation [transforming growth factor β(TGF-β) and interferon] have been found to be effective in the production of pleurodesis. The use of povidone-iodine, autologous blood, and polidocanol has...
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References and Further Reading
Antony, V. B., Loddenkemper, R., Astoul, P., et al. (2000). Management of malignant pleural effusions. American Journal of Respiratory and Critical Care Medicine, 162, 1987–2001.
Attanoos, R. L., & Gibbs, A. R. (2004). The pathology associated with therapeutic procedures in malignant mesothelioma. Histopathology, 45(4), 393–397.
Fysh, E. T., Tan, S. K., Read, C. A., et al. (2012). Pleurodesis outcome in malignant pleural mesothelioma. Thorax, 68(6), 594–596.
Hurewitz, A. N., Lidonicci, K., Wu, C. L., et al. (1994). Histologic changes of doxycycline pleurodesis in rabbits. Effect of concentration. Chest, 106(4), 1241–1245.
Kennedy, L., Harley, R. A., Sahn, S. A., et al. (1995). Talc slurry pleurodesis. Pleural fluid and histologic analysis. Chest, 107(6), 1707–1712.
Ramani, P., & Shah, A. (1993). Lymphangiomatosis. Histologic and immunohistochemical analysis of four cases. The American Journal of Surgical Pathology, 17(4), 329–335.
Teixeira, L. R., Vargas, F. S., Acencio, M. M. P., et al. (2006). Experimental pleurodesis induced by antibiotics (Macrolides of quinolones). Clinics, 61(6), 559–564.
Vargas, F. S., Teixeira, L. R., Antonangelo, L., et al. (2001). Experimental pleurodesis in rabbits induced by silver nitrate or talc: 1-year follow-up. Chest, 119(5), 1516–1520.
Walker-Renard, P. B., Vaughan, L. M., & Sahn, S. A. (1994). Chemical pleurodesis for malignant pleural effusions. Annals of Internal Medicine, 120, 56–64.
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Kawai, T., Hebisawa, A. (2018). Histologic Changes of Pleurodesis. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_364
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DOI: https://doi.org/10.1007/978-3-319-66796-6_364
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