Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Histologic Changes of Pleurodesis

  • Toshiaki KawaiEmail author
  • Akira Hebisawa
Reference work entry


Obliteration of pleural cavity; Pleurosclerosis; Scarification of pleura


Pleurodesis, from the Greek pleura and desis (binding together), is the artificial production of adhesions between the parietal and visceral pleura for the treatment of a persistent pneumothorax or severe pleural effusion, and mesothelioma, according to the 29th edition of Dorland’s Illustrated Medical Dictionary.

Pleurodesis has been performed since the beginning of the twentieth century, and various agents have been used. However, the search for the ideal sclerosing agent continues.

Among the chemicals that have been used to produce pleurodesis are the following: talc, Corynebacterium parvum, macrolides, quinolones, doxycycline, tetracycline (TCN), and bleomycin. Recently, biological mediators of inflammation [transforming growth factor β(TGF-β) and interferon] have been found to be effective in the production of pleurodesis. The use of povidone-iodine, autologous blood, and polidocanol has...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Antony, V. B., Loddenkemper, R., Astoul, P., et al. (2000). Management of malignant pleural effusions. American Journal of Respiratory and Critical Care Medicine, 162, 1987–2001.CrossRefGoogle Scholar
  2. Attanoos, R. L., & Gibbs, A. R. (2004). The pathology associated with therapeutic procedures in malignant mesothelioma. Histopathology, 45(4), 393–397.CrossRefPubMedGoogle Scholar
  3. Fysh, E. T., Tan, S. K., Read, C. A., et al. (2012). Pleurodesis outcome in malignant pleural mesothelioma. Thorax, 68(6), 594–596.CrossRefGoogle Scholar
  4. Hurewitz, A. N., Lidonicci, K., Wu, C. L., et al. (1994). Histologic changes of doxycycline pleurodesis in rabbits. Effect of concentration. Chest, 106(4), 1241–1245.CrossRefPubMedGoogle Scholar
  5. Kennedy, L., Harley, R. A., Sahn, S. A., et al. (1995). Talc slurry pleurodesis. Pleural fluid and histologic analysis. Chest, 107(6), 1707–1712.CrossRefPubMedGoogle Scholar
  6. Ramani, P., & Shah, A. (1993). Lymphangiomatosis. Histologic and immunohistochemical analysis of four cases. The American Journal of Surgical Pathology, 17(4), 329–335.CrossRefPubMedGoogle Scholar
  7. Teixeira, L. R., Vargas, F. S., Acencio, M. M. P., et al. (2006). Experimental pleurodesis induced by antibiotics (Macrolides of quinolones). Clinics, 61(6), 559–564.CrossRefPubMedGoogle Scholar
  8. Vargas, F. S., Teixeira, L. R., Antonangelo, L., et al. (2001). Experimental pleurodesis in rabbits induced by silver nitrate or talc: 1-year follow-up. Chest, 119(5), 1516–1520.CrossRefPubMedGoogle Scholar
  9. Walker-Renard, P. B., Vaughan, L. M., & Sahn, S. A. (1994). Chemical pleurodesis for malignant pleural effusions. Annals of Internal Medicine, 120, 56–64.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyNational Defense Medical CollegeTokorozawaJapan
  2. 2.National Hospital Organization Tokyo HospitalKiyoseJapan