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Mediastinal Anaplastic Large-Cell Lymphoma

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Pathology of the Pleura and Mediastinum

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Ki-1 lymphoma; Ki-1-positive large-cell lymphoma; Lymphoma; Large-cell anaplastic, CD30-positive; Malignant histiocytosis

Definition

Anaplastic large-cell lymphoma (ALCL) is a mature T-cell neoplasm characterized by strong CD30 expression and the presence of “hallmark cells,” which are usually large atypical cells with kidney- or horseshoe-shaped nuclei, abundant cytoplasm, and characteristic perinuclear (Golgi) clearing. ALCL also tends to have a cohesive growth pattern and a propensity for lymph node sinusoidal distribution. The current 2008 WHO classification of hematolymphoid neoplasms distinguishes an ALK-positive and an ALK-negative variant of ALCL. ALK-positive ALCL is characterized by translocations involving the ALK gene, resulting in overexpression of novel chimeric ALK proteins. ALK-negative ALCL is morphologically and immunophenotypically similar to ALK-positive ALCL but lacks ALK gene rearrangements and ALK protein expression. It is a provisional entity in the...

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References and Further Reading

  • Armitage, J. O. (2012). The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management. American Journal of Hematology, 87(5), 511–519.

    Article  PubMed  Google Scholar 

  • Falini, B. (2001). Anaplastic large cell lymphoma: Pathological, molecular and clinical features. British Journal of Haematology, 114(4), 741–760.

    Article  PubMed  CAS  Google Scholar 

  • Medeiros, L. J., & Elenitoba-Johnson, K. S. (2007). Anaplastic large cell lymphoma. American Journal of Clinical Pathology, 127(5), 707–722.

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  • Merkel, O., Hamacher, F., Sifft, E., Kenner, L., & Greil, R. (2012). Novel therapeutic options in anaplastic large cell lymphoma: Molecular targets and immunological tools. Molecular Cancer Therapeutics, 10(7), 1127–1136.

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  • Savage, K. J., Harris, N. L., Vose, J. M., Ullrich, F., Jaffe, E. S., Connors, J. M., et al. (2008). ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK + ALCL and peripheral T-cell lymphoma, not otherwise specified: Report from the International Peripheral T-Cell Lymphoma Project. Blood, 111(12), 5496–5504.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, WI, USA

    Dr. Horatiu Olteanu M.D., Ph.D.

  2. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Dr. Horatiu Olteanu M.D., Ph.D.

Authors
  1. Dr. Horatiu Olteanu M.D., Ph.D.
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Corresponding author

Correspondence to Horatiu Olteanu M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Pathology, The University of Mississippi Medical School, The University of Mississippi Medical Center, Jackson, MS, USA

    Timothy Craig Allen

  2. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA

    Saul Suster

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Olteanu, H. (2018). Mediastinal Anaplastic Large-Cell Lymphoma. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_34

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  • DOI: https://doi.org/10.1007/978-3-319-66796-6_34

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-66795-9

  • Online ISBN: 978-3-319-66796-6

  • eBook Packages: MedicineReference Module Medicine

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