Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Mediastinal Anaplastic Large-Cell Lymphoma

  • Horatiu OlteanuEmail author
Reference work entry


Ki-1 lymphoma; Ki-1-positive large-cell lymphoma; Lymphoma; Large-cell anaplastic, CD30-positive; Malignant histiocytosis


Anaplastic large-cell lymphoma (ALCL) is a mature T-cell neoplasm characterized by strong CD30 expression and the presence of “hallmark cells,” which are usually large atypical cells with kidney- or horseshoe-shaped nuclei, abundant cytoplasm, and characteristic perinuclear (Golgi) clearing. ALCL also tends to have a cohesive growth pattern and a propensity for lymph node sinusoidal distribution. The current 2008 WHO classification of hematolymphoid neoplasms distinguishes an ALK-positive and an ALK-negative variant of ALCL. ALK-positive ALCL is characterized by translocations involving the ALK gene, resulting in overexpression of novel chimeric ALK proteins. ALK-negative ALCL is morphologically and immunophenotypically similar to ALK-positive ALCL but lacks ALK gene rearrangements and ALK protein expression. It is a provisional entity in the...

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References and Further Reading

  1. Armitage, J. O. (2012). The aggressive peripheral T-cell lymphomas: 2012 update on diagnosis, risk stratification, and management. American Journal of Hematology, 87(5), 511–519.PubMedCrossRefGoogle Scholar
  2. Falini, B. (2001). Anaplastic large cell lymphoma: Pathological, molecular and clinical features. British Journal of Haematology, 114(4), 741–760.PubMedCrossRefGoogle Scholar
  3. Medeiros, L. J., & Elenitoba-Johnson, K. S. (2007). Anaplastic large cell lymphoma. American Journal of Clinical Pathology, 127(5), 707–722.PubMedCrossRefGoogle Scholar
  4. Merkel, O., Hamacher, F., Sifft, E., Kenner, L., & Greil, R. (2012). Novel therapeutic options in anaplastic large cell lymphoma: Molecular targets and immunological tools. Molecular Cancer Therapeutics, 10(7), 1127–1136.CrossRefGoogle Scholar
  5. Savage, K. J., Harris, N. L., Vose, J. M., Ullrich, F., Jaffe, E. S., Connors, J. M., et al. (2008). ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK + ALCL and peripheral T-cell lymphoma, not otherwise specified: Report from the International Peripheral T-Cell Lymphoma Project. Blood, 111(12), 5496–5504.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Department of Pathology, Mayo ClinicRochesterUSA