Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Liposarcoma, Mediastinal

  • Giovanni FalconieriEmail author
Reference work entry




Liposarcomas may occur either in the anterior or the posterior mediastinum (Hahn and Fletcher 2007; Klimstra et al. 1995; Ortega et al. 2014). Tumors of the anterior mediastinum may grow in intimate association with the thymus. Presenting symptoms are related to compression exerted by a tumor on the adjacent anatomic structures; they include shortness of breath as well as cough or palpitation. However about one third of cases are discovered incidentally. Like lipomas, liposarcomas have also been described in obese patients with systemic lipomatosis.

Clinical Features

  • Incidence

    Exact figures are not available; however, MLS are considered uncommon tumors accounting for less than 1% of all mediastinal tumors.

  • Age

    Patients are mostly adults, with rare cases documented in the pediatric age.

  • Sex

    No sex predilection.

  • Site

    Commonly seen in the anterior mediastinum; however, cases have been recently described in the posterior sector.

  • Treatment

    Complete surgical excision...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Hahn, H. P., & Fletcher, C. D. (2007). Primary mediastinal liposarcoma: Clinicopathologic analysis of 24 cases. American Journal of Surgical Pathology, 31(12), 1868–1874.CrossRefPubMedGoogle Scholar
  2. Klimstra, D. S., Moran, C. A., Perino, G., Koss, M. N., & Rosai, J. (1995). Liposarcoma of the anterior mediastinum and thymus. A clinicopathologic study of 28 cases. American Journal of Surgical Pathology, 19(7), 782–791.CrossRefPubMedGoogle Scholar
  3. Ortega, P., Suster, D., Falconieri, G., Zambrano, E., Moran, C. A., Morrison, C., et al. (2014). Liposarcomas of the posterior mediastinum: Clinicopathologic study of 18 cases. Mod Pathol, 28(5), 721–731.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyUniversity of Trieste School of MedicineTriesteItaly