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Pathology of the Pleura and Mediastinum pp 160–169Cite as

Hodgkin Lymphoma, Mediastinal

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Hodgkin’s disease

Definition

Hodgkin lymphoma (HL) is a B-cell neoplasm characterized morphologically by the presence of relatively rare atypical neoplastic cells (Reed-Sternberg cells, Hodgkin cells, or LP cells) in a background of nonneoplastic, variably heterogeneous inflammatory infiltrate. HL is broadly divided in classical HL, which represent 95% of cases, and nodular lymphocyte predominant HL (NLPHL), which constitutes the remainder 5%. Classical HL is further subdivided into four categories: nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted, based on cellular composition and different histologic pattern (Mani and Jaffe 2009).

Clinical Features

  • Incidence

    In the US and Western Europe, HL has an incidence of 3–5 cases/100,000/year, while in Japan the incidence is about threefold lower. In patients with AIDS, the risk of developing HL is ten times higher than in an HIV-negative individual.

  • Age

    Classical HL has a bimodal age distribution, with...

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References and Further Reading

  • Eberle, F. C., Mani, H., & Jaffe, E. S. (2009). Histopathology of Hodgkin’s lymphoma. Cancer Journal, 15(2), 129–137.

    Article  Google Scholar 

  • Eichenauer, D. A., Engert, A., & Dreyling, M. (2011). Hodgkin's lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 22(Suppl 6), vi55–vi58.

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  • Hoppe, R. T., Advani, R. H., Ai, W. Z., Ambinder, R. F., Bello, C. M., Bierman, P. J., et al. (2011). Hodgkin lymphoma. Journal of the National Comprehensive Cancer Network, 9(9), 1020–1058.

    Article  CAS  PubMed  Google Scholar 

  • Kuppers, R. (2009). Molecular biology of Hodgkin lymphoma. Hematology American Society of Hematology Education Program, 2009(1), 491–496.

    Article  Google Scholar 

  • Mani, H., & Jaffe, E. S. (2009). Hodgkin lymphoma: An update on its biology with new insights into classification. Clinical Lymphoma & Myeloma, 9(3), 206–216.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Medical College of Wisconsin, Milwaukee, WI, USA

    Dr. Horatiu Olteanu M.D., Ph.D.

  2. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Dr. Horatiu Olteanu M.D., Ph.D.

Authors
  1. Dr. Horatiu Olteanu M.D., Ph.D.
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Corresponding author

Correspondence to Horatiu Olteanu M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Pathology, The University of Mississippi Medical School, The University of Mississippi Medical Center, Jackson, MS, USA

    Timothy Craig Allen

  2. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA

    Saul Suster

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Cite this entry

Olteanu, H. (2018). Hodgkin Lymphoma, Mediastinal. In: Allen, T.C., Suster, S. (eds) Pathology of the Pleura and Mediastinum. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-66796-6_25

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  • DOI: https://doi.org/10.1007/978-3-319-66796-6_25

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-66795-9

  • Online ISBN: 978-3-319-66796-6

  • eBook Packages: MedicineReference Module Medicine

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