Hodgkin Lymphoma, Mediastinal
Hodgkin lymphoma (HL) is a B-cell neoplasm characterized morphologically by the presence of relatively rare atypical neoplastic cells (Reed-Sternberg cells, Hodgkin cells, or LP cells) in a background of nonneoplastic, variably heterogeneous inflammatory infiltrate. HL is broadly divided in classical HL, which represent 95% of cases, and nodular lymphocyte predominant HL (NLPHL), which constitutes the remainder 5%. Classical HL is further subdivided into four categories: nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted, based on cellular composition and different histologic pattern (Mani and Jaffe 2009).
In the US and Western Europe, HL has an incidence of 3–5 cases/100,000/year, while in Japan the incidence is about threefold lower. In patients with AIDS, the risk of developing HL is ten times higher than in an HIV-negative individual.
Classical HL has a bimodal age distribution, with...