Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Mediastinal Granular Cell Tumor

  • Annikka WeissferdtEmail author
  • Cesar A. Moran
Reference work entry


Abrikossoff tumor; Granular cell myoblastoma


Granular cell tumors have been known to exist since the mid-nineteenth century when the first cases were reported in the German literature. Initially believed to be of myoblastic origin, application of electron microscopy and immunohistochemistry has subsequently shown increasing evidence that granular cell tumors are of neural origin and likely derived from Schwann cells. The vast majority of granular cell tumors occur in the head and neck area, most commonly the tongue, but almost any anatomic location can harbor these lesions. The majority of granular cell tumors are benign neoplasms; malignant variants are rare and estimated to represent 1–2% of granular cell tumors and 0.2% of all soft tissue sarcomas. A small subset of patients present with multiple lesions either in the same organ or in multiple different sites (Ordonez 1999; Fanburg-Smith et al. 1998; Marchevsky 1999).

Clinical Features

  • Incidence

    Granular cell...

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References and Further Reading

  1. Chamberlain, B. K., McClain, C. M., Gonzalez, R. S., Coffin, C. M., & Cates, J. M. (2014). Alveolar soft part sarcoma and granular cell tumor: An immunohistochemical comparison study. Human Pathology, 45, 1039–1044.PubMedCrossRefGoogle Scholar
  2. De Luca, G., Luciano, A., Benincasa, G., Sessa, R., & Peterutti, F. (2013). Giant malignant granular cell tumor (GCT) of the posterior mediastinum. Journal of Thoracic Oncology, 8, 1107–1108.PubMedCrossRefGoogle Scholar
  3. Fanburg-Smith, J. C., Meis-Kindblom, J. M., Fante, R., & Kindblom, L. G. (1998). Malignant granular cell tumor of soft tissue: Diagnostic criteria and clinicopathologic correlation. American Journal of Surgical Pathology, 22, 779–794.PubMedCrossRefGoogle Scholar
  4. Marchevsky, A. (1999). Mediastinal tumors of peripheral nervous system origin. Seminars in Diagnostic Pathology, 16, 65–78.PubMedGoogle Scholar
  5. Ordonez, N. G. (1999). Granular cell tumor: A review and update. Advances in Anatomic Pathology, 6, 186–203.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.MD Anderson Cancer CenterHoustonUSA