Abstract
Improvements in socio-economic and sanitary conditions have led to an emerging increase in the number of very old people, including centenarians. Therefore, studies on the physiological and pathological processes involved in ageing have become critically important. Centenarians and supercentenarians are the best models of successful ageing, which is a process influenced by environmental and biological factors. Centenarians reach the extreme limits of lifespan by overcoming major age-related diseases. In this study, inflammation, the immune system, genetics, and metabolism were examined in order to understand the secret of centenarians’ long survival. Several studies have suggested that centenarians are equipped with protective molecules and efficient biochemical pathways, along with well-preserved immune functions. However, a complication in the study of centenarians is their extremely variable clinical conditions. Among centenarians, there are both frail individuals with multiple pathologies and healthy subjects, although some of them show signs of the advanced ageing process. In their B-cell compartments, centenarians seem to show the typical age-related changes observed in the elderly; surprisingly, however, their offspring show well-preserved humoral immunity. Therefore, centenarian offspring, who are predisposed to longer survival in a healthy status, seem to be suitable subjects for ageing studies.
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Bulati, M., Caruso, C., Colonna-Romano, G. (2018). B Cells in Centenarians and Their Offspring. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_88-1
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