Abstract
Oxidative phosphorylation is a mitochondrial reaction chain that generates energy in the form of ATP (adenosine triphosphate) for cellular functions. As a by-product, it produces reactive oxygen species (ROS) that are essential, e.g., for cellular signaling and immune responses but in excessive amounts detrimental for cells. Aging is accompanied by reduced oxidative phosphorylation, decreased ATP production, increased ROS production, and diminished mitophagy that removes dysfunctional organelles by autophagy. Aged mitochondria are also prone to damages in their DNA (mtDNA). These changes create danger signals that are efficiently sensed by NLRP3, an intracellular pattern recognition receptor forming an intracellular protein complex for caspase-1-mediated activation of pro-inflammatory cytokines IL-1β and IL-18. Mitochondrial ROS and NLRP3 participate in the release of mtDNA into cytosol where its oxidized form further promotes inflammasome activation. The physical interaction of NLRP3 with mitochondria at the interface between the endoplasmic reticulum (ER) and mitochondria called mitochondria-associated ER membranes (MAMs) as well as with other mitochondria-related proteins connects NLRP3 closely to the functionality of mitochondria and provides a direct link from mitochondrial dysfunction to chronic age-related inflammation.
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References
Allam R, Lawlor KE, Yu EC et al (2014) Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. EMBO Rep 15(9):982–990. https://doi.org/10.15252/embr.201438463
Anderson OA, Finkelstein A, Shima DT (2013) A2E induces IL-1ss production in retinal pigment epithelial cells via the NLRP3 inflammasome. PLoS One 8(6):e67263. https://doi.org/10.1371/journal.pone.0067263
Antonopoulos C, Russo HM, El Sanadi C et al (2015) Caspase-8 as an effector and regulator of NLRP3 inflammasome signaling. J Biol Chem 290(33):20167–20184. https://doi.org/10.1074/jbc.M115.652321
Area-Gomez E, Schon EA (2016) Mitochondria-associated ER membranes and Alzheimer disease. Curr Opin Genet Dev 38:90–96. doi:S0959-437X(16)30029-6 [pii]
Area-Gomez E, de Groof AJ, Boldogh I et al (2009) Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol 175(5):1810–1816. https://doi.org/10.2353/ajpath.2009.090219
Aspinall R, Lapenna A, B-Lynch C et al (2014) Cellular signaling pathways in immune aging and regeneration. Biochem Soc Trans 42(3):651–656. https://doi.org/10.1042/BST20140021
Baroja-Mazo A, Martin-Sanchez F, Gomez AI et al (2014) The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 15(8): 738–748. https://doi.org/10.1038/ni.2919
Bektas A, Zhang Y, Wood WH 3rd et al (2013) Age-associated alterations in inducible gene transcription in human CD4+ T lymphocytes. Aging (Albany NY) 5(1):18–36. https://doi.org/10.18632/aging.100522
Bonomini F, Rodella LF, Rezzani R (2015) Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 6(2):109–120. https://doi.org/10.14336/AD.2014.0305
Brookes PS, Yoon Y, Robotham JL et al (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Phys Cell Phys 287(4):C817–C833. https://doi.org/10.1152/ajpcell.00139.2004
Camell CD, Nguyen KY, Jurczak MJ et al (2015) Macrophage-specific de Novo synthesis of ceramide is dispensable for inflammasome-driven inflammation and insulin resistance in obesity. J Biol Chem 290(49):29402–29413. https://doi.org/10.1074/jbc.M115.680199
Cannizzo ES, Clement CC, Sahu R et al (2011) Oxidative stress, inflamm-aging and immunosenescence. J Proteome 74(11):2313–2323. https://doi.org/10.1016/j.jprot.2011.06.005
Chen CL, Lin CF, Chang WT et al (2008) Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood 111(8):4365–4374. https://doi.org/10.1182/blood-2007-08-106336
Chen L, Na R, Boldt E et al (2015) NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure. Neurobiol Aging 36(9):2533–2543. https://doi.org/10.1016/j.neurobiolaging.2015.05.018
Cho MH, Cho K, Kang HJ et al (2014) Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 10(10):1761–1775. https://doi.org/10.4161/auto.29647
Chu CT, Ji J, Dagda RK et al (2013) Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol 15(10): 1197–1205. https://doi.org/10.1038/ncb2837
Chung KW, Kim DH, Park MH et al (2013) Recent advances in calorie restriction research on aging. Exp Gerontol 48(10):1049–1053. https://doi.org/10.1016/j.exger.2012.11.007
Cowart LA (2009) Sphingolipids: players in the pathology of metabolic disease. Trends Endocrinol Metab 20(1):34–42. https://doi.org/10.1016/j.tem.2008.09.004
Cruz CM, Rinna A, Forman HJ et al (2007) ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 282(5):2871–2879. https://doi.org/10.1074/jbc.M608083200
Cuervo AM, Bergamini E, Brunk UT et al (2005) Autophagy and aging: the importance of maintaining “clean” cells. Autophagy 1(3):131–140. https://doi.org/10.4161/auto.1.3.2017
Davis BK, Wen H, Ting JP (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 29:707–735. https://doi.org/10.1146/annurev-immunol-031210-101405
DelaRosa O, Pawelec G, Peralbo E et al (2006) Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity. Biogerontology 7(5–6):471–481. https://doi.org/10.1007/s10522-006-9062-6
Dostert C, Petrilli V, Van Bruggen R et al (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320(5876):674–677. https://doi.org/10.1126/science.1156995
Dostert C, Guarda G, Romero JF et al (2009) Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One 4(8):e6510. https://doi.org/10.1371/journal.pone.0006510
Doyle SL, Campbell M, Ozaki E et al (2012) NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med 18(5):791–798. https://doi.org/10.1038/nm.2717
Feher J, Kovacs I, Artico M et al (2006) Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging 27(7):983–993. https://doi.org/10.1016/j.neurobiolaging.2005.05.012
Feng Y, He D, Yao Z et al (2014) The machinery of macroautophagy. Cell Res 24(1):24–41. https://doi.org/10.1038/cr.2013.168
Fink SL, Cookson BT (2005) Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 73(4):1907–1916. https://doi.org/10.1128/IAI.73.4.1907-1916.2005
Franceschi C, Bonafe M, Valensin S et al (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254. https://doi.org/10.1111/j.1749-6632.2000.tb06651.x
Garlanda C, Dinarello CA, Mantovani A (2013) The interleukin-1 family: back to the future. Immunity 39(6):1003–1018. https://doi.org/10.1016/j.immuni.2013.11.010
Goldberg EL, Dixit VD (2015) Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev 265(1):63–74. https://doi.org/10.1111/imr.12295
Gonzalvez F, Schug ZT, Houtkooper RH et al (2008) Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol 183(4):681–696. https://doi.org/10.1083/jcb.200803129
Grimm A, Mensah-Nyagan AG, Eckert A (2016) Alzheimer, mitochondria and gender. Neurosci Biobehav Rev 67:89–101. https://doi.org/10.1016/j.neubiorev.2016.04.012
Gross O, Thomas CJ, Guarda G et al (2011) The inflammasome: an integrated view. Immunol Rev 243(1):136–151. https://doi.org/10.1111/j.1600-065X.2011.01046.x
Gurung P, Kanneganti TD (2015) Novel roles for caspase-8 in IL-1beta and inflammasome regulation. Am J Pathol 185(1):17–25. https://doi.org/10.1016/j.ajpath.2014.08.025
Halle A, Hornung V, Petzold GC et al (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9(8):857–865. https://doi.org/10.1038/ni.1636
Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11(3):298–300
Hewinson J, Moore SF, Glover C et al (2008) A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes. J Immunol 180(12):8410–8420. https://doi.org/10.4049/jimmunol.180.12.8410
Hulbert AJ, Pamplona R, Buffenstein R et al (2007) Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev 87(4):1175–1213. doi:87/4/1175 [pii]
Ichinohe T, Yamazaki T, Koshiba T et al (2013) Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. Proc Natl Acad Sci USA 110(44): 17963–17968. https://doi.org/10.1073/pnas.1312571110
Iyer SS, He Q, Janczy JR et al (2013) Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity 39(2):311–323. https://doi.org/10.1016/j.immuni.2013.08.001
Kaarniranta K, Salminen A, Haapasalo A et al (2011) Age-related macular degeneration (AMD): Alzheimer’s disease in the eye? J Alzheimers Dis 24(4):615–631. https://doi.org/10.3233/JAD-2011-101908
Kaarniranta K, Sinha D, Blasiak J et al (2013) Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9(7):973–984. https://doi.org/10.4161/auto.24546
Kang TB, Yang SH, Toth B et al (2013) Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 38(1):27–40. https://doi.org/10.1016/j.immuni.2012.09.015
Kauppinen A, Niskanen H, Suuronen T et al (2012) Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD). Immunol Lett 147(1–2):29–33. https://doi.org/10.1016/j.imlet.2012.05.005
Kauppinen A, Paterno JJ, Blasiak J et al (2016) Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci 73(9):1765–1786. https://doi.org/10.1007/s00018-016-2147-8
Kawai T, Takahashi K, Sato S et al (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6(10):981–988. https://doi.org/10.1038/ni1243
Kim YW, Moon JS, Seo YJ et al (2012) Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells. Biochem Biophys Res Commun 420(2):462–466. https://doi.org/10.1016/j.bbrc.2012.03.020
Krone CL, Trzcinski K, Zborowski T et al (2013) Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization. Infect Immun 81(12):4615–4625. https://doi.org/10.1128/IAI.00618-13
Kummer JA, Broekhuizen R, Everett H et al (2007) Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 55(5):443–452. https://doi.org/10.1369/jhc.6A7101.2006
Lallukka S, Yki-Jarvinen H (2016) Non-alcoholic fatty liver disease and risk of type 2 diabetes. Best Pract Res Clin Endocrinol Metab 30(3):385–395. https://doi.org/10.1016/j.beem.2016.06.006
Lamkanfi M, Sarkar A, Vande Walle L et al (2010) Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 185(7):4385–4392. https://doi.org/10.4049/jimmunol.1000803
LeBlanc PM, Doggett TA, Choi J et al (2014) An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor. J Biol Chem 289(11): 7777–7786. https://doi.org/10.1074/jbc.M113.541474
Lee JW, Kim LE, Shim HJ et al (2016) A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation. Biochem Biophys Res Commun 474(3): 587–593. https://doi.org/10.1016/j.bbrc.2016.04.080
Liu RT, Gao J, Cao S et al (2013) Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration. Invest Ophthalmol Vis Sci 54(3):2225–2237. https://doi.org/10.1167/iovs.12-10849
Lopez-Lluch G, Santos-Ocana C, Sanchez-Alcazar JA et al (2015) Mitochondrial responsibility in ageing process: innocent, suspect or guilty. Biogerontology 16(5):599–620. https://doi.org/10.1007/s10522-015-9585-9
Man SM, Kanneganti TD (2015) Regulation of inflammasome activation. Immunol Rev 265(1): 6–21. https://doi.org/10.1111/imr.12296
Martinon F (2010) Signaling by ROS drives inflammasome activation. Eur J Immunol 40(3): 616–619. https://doi.org/10.1002/eji.200940168
Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10(2):417–426
Meylan E, Curran J, Hofmann K et al (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437(7062):1167–1172. https://doi.org/10.1038/nature04193
Nakahira K, Haspel JA, Rathinam VA et al (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12(3):222–230. https://doi.org/10.1038/ni.1980
Netea MG, Nold-Petry CA, Nold MF et al (2009) Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113(10):2324–2335. https://doi.org/10.1182/blood-2008-03-146720
Park S, Juliana C, Hong S et al (2013) The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol 191(8):4358–4366. https://doi.org/10.4049/jimmunol.1301170
Pelegrin P, Surprenant A (2006) Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 25(21):5071–5082. https://doi.org/10.1038/sj.emboj.7601378
Petrilli V, Papin S, Dostert C et al (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14(9):1583–1589. https://doi.org/10.1038/sj.cdd.4402195
Piippo N, Korkmaz A, Hytti M et al (2014) Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells. Biochim Biophys Acta 1843(12): 3038–3046. https://doi.org/10.1016/j.bbamcr.2014.09.015
Ponnappan S, Ponnappan U (2011) Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal 14(8):1551–1585. https://doi.org/10.1089/ars.2010.3228
Ramirez A, Rathinam V, Fitzgerald KA et al (2012) Defective pro-IL-1beta responses in macrophages from aged mice. Immun Ageing 9(1):27. https://doi.org/10.1186/1742-4933-9-27
Reuven EM, Fink A, Shai Y (2014) Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family. Biochim Biophys Acta 1838(6):1586–1593. https://doi.org/10.1016/j.bbamem.2014.01.020
Salminen A, Kaarniranta K, Kauppinen A (2012a) Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) 4(3):166–175
Salminen A, Ojala J, Kaarniranta K et al (2012b) Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci 69(18):2999–3013. https://doi.org/10.1007/s00018-012-0962-0
Saxena G, Chen J, Shalev A (2010) Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem 285(6):3997–4005. https://doi.org/10.1074/jbc.M109.034421
Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418(6894):191–195. https://doi.org/10.1038/nature00858
Schon EA, Area-Gomez E (2013) Mitochondria-associated ER membranes in Alzheimer disease. Mol Cell Neurosci 55:26–36. https://doi.org/10.1016/j.mcn.2012.07.011
Shaw AC, Goldstein DR, Montgomery RR (2013) Age-dependent dysregulation of innate immunity. Nat Rev Immunol 13(12):875–887. https://doi.org/10.1038/nri3547
Shenoy AR, Wellington DA, Kumar P et al (2012) GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 336(6080):481–485. https://doi.org/10.1126/science.1217141
Shi H, Zhang Z, Wang X et al (2015) Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress. Biochem Biophys Res Commun 463(4):1071–1076. https://doi.org/10.1016/j.bbrc.2015.06.060
Sobenin IA, Zhelankin AV, Sinyov VV et al (2015) Mitochondrial aging: focus on mitochondrial DNA damage in atherosclerosis – a mini-review. Gerontology 61(4):343–349. https://doi.org/10.1159/000368923
Song F, Ma Y, Bai XY et al (2015) The expression changes of inflammasomes in the aging rat kidneys. J Gerontol A Biol Sci Med Sci. https://doi.org/10.1093/gerona/glv078
Stojadinovic O, Minkiewicz J, Sawaya A et al (2013) Deep tissue injury in development of pressure ulcers: a decrease of inflammasome activation and changes in human skin morphology in response to aging and mechanical load. PLoS One 8(8):e69223. https://doi.org/10.1371/journal.pone.0069223
Stout-Delgado HW, Vaughan SE, Shirali AC et al (2012) Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. J Immunol 188(6):2815–2824. https://doi.org/10.4049/jimmunol.1103051
Strowig T, Henao-Mejia J, Elinav E et al (2012) Inflammasomes in health and disease. Nature 481(7381):278–286. https://doi.org/10.1038/nature10759
Subramanian N, Natarajan K, Clatworthy MR et al (2013) The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell 153(2):348–361. https://doi.org/10.1016/j.cell.2013.02.054
Sutterwala FS, Haasken S, Cassel SL (2014) Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci 1319:82–95. https://doi.org/10.1111/nyas.12458
Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: the convergence of multiple signaling pathways on ROS production? Nat Rev Immunol 10(3):210–215. https://doi.org/10.1038/nri2725
Tumurkhuu G, Shimada K, Dagvadorj J et al (2016) Ogg1-dependent DNA repair regulates NLRP3 inflammasome and prevents atherosclerosis. Circ Res. https://doi.org/10.1161/CIRCRESAHA.116.308362
van Bruggen R, Koker MY, Jansen M et al (2010) Human NLRP3 inflammasome activation is Nox1-4 independent. Blood 115(26):5398–5400. https://doi.org/10.1182/blood-2009-10-250803
van Zoelen MA, Yang H, Florquin S et al (2009) Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo. Shock 31(3):280–284. https://doi.org/10.1097/SHK.0b013e318186262d
Vandanmagsar B, Youm YH, Ravussin A et al (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17(2):179–188. https://doi.org/10.1038/nm.2279
Vince JE, Silke J (2016) The intersection of cell death and inflammasome activation. Cell Mol Life Sci 73(11–12):2349–2367. https://doi.org/10.1007/s00018-016-2205-2
Wagar LE, Gentleman B, Pircher H et al (2011) Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response. PLoS One 6(8):e23698. https://doi.org/10.1371/journal.pone.0023698
Wen H, Gris D, Lei Y et al (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12(5):408–415. https://doi.org/10.1038/ni.2022
Wu X, Hakimi M, Wortmann M et al (2015) Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. Immun Ageing 12:15. https://doi.org/10.1186/s12979-015-0043-y. eCollection 2015
Xu LG, Wang YY, Han KJ et al (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 19(6):727–740. doi:S1097-2765(05)01556-X [pii]
Youm YH, Kanneganti TD, Vandanmagsar B et al (2012) The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep 1(1):56–68. https://doi.org/10.1016/j.celrep.2011.11.005
Youm YH, Grant RW, McCabe LR et al (2013) Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab 18(4):519–532. https://doi.org/10.1016/j.cmet.2013.09.010
Zhang X, Zhang JH, Chen XY et al (2015) Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal 22(10):848–870. https://doi.org/10.1089/ars.2014.5868
Zhao C, Gillette DD, Li X et al (2014) Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation. J Biol Chem 289(24):17020–17029. https://doi.org/10.1074/jbc.M114.563114
Zhou R, Tardivel A, Thorens B et al (2010) Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 11(2):136–140. https://doi.org/10.1038/ni.1831
Zhou R, Yazdi AS, Menu P et al (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469(7329):221–225. https://doi.org/10.1038/nature09663
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Kauppinen, A. (2018). Mitochondria-Associated Inflammasome Activation and Its Impact on Aging and Age-Related Diseases. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_107-1
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