Synonyms
Solid Papillary Neuroendocrine Breast Carcinoma
Definition
Solid papillary carcinoma (SPC) is described in the 2012 WHO classification within the group of the intraductal papillary lesions and is defined as a variant of papillary carcinoma characterized by multiple solid nodules of neoplastic cells arranged around multiple fibrovascular spaces. Despite the lack of the external myoepithelial layer, these lesions are currently considered as noninvasive (Lakhani et al. 2012). However, cases of true invasive SPC exist.
Clinical Features
Incidence
SPC is a rare entity, accounting for 1–2% of breast carcinomas (BCs) (Otsuki et al. 2007).
Age
It usually affects women in the seventh decade, with a mean age of 73.2 years (Maluf and Koerner 1995).
Sex
It is more frequently observed in female patients, but it has been sporadically described in men (Nassar et al. 2006).
Side
SPC is typically unifocal and localized in the central region of the breast (Guo et al. 2016), although a single...
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References and Further Reading
Burt, M., Madan, R., & Fan, F. (2016). Metastatic gastrinoma in the breast mimicking primary solid papillary carcinoma. Human Pathology, 56, 143–146.
Cui, X., & Wei, S. (2015). Composite encapsulated papillary carcinoma and solid papillary carcinoma. Pathology International, 65, 133–137.
Duprez, R., Wilkerson, P. M., Lacroix-Triki, M., Lambros, M. B., MacKay, A., A’Hern, R., Gauthier, A., et al. (2012). Immunophenotypic and genomic characterization of papillary carcinomas of the breast. The Journal of Pathology, 226, 427–441.
Guo, S., Wang, Y., Rohr, J., Fan, C., Li, Q., Li, X., & Wang, Z. (2016). Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. The Breast, 26, 67–72.
Lakhani, S. R., Ellis, I. O., Schnitt, S. J., Tan, P. H., van de Vijver, M. J. (2012). WHO classification of tumours of the breast. World Health Organization classification of tumours. Lyon, IARC press. ISBN-10: 9283224337.
Maluf, H. M., & Koerner, F. C. (1995). Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. The American Journal of Surgical Pathology, 19, 1237–1244.
Nassar, H., Qureshi, H., Adsay, N. V., Volkanadsay, N., & Visscher, D. (2006). Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. The American Journal of Surgical Pathology, 30, 501–507.
Ni, Y. B., & Tse, G. M. (2016). Pathological criteria and practical issues in papillary lesions of the breast – A review. Histopathology, 68, 22–32.
Otsuki, Y., Yamada, M., Shimizu, S., Suwa, K., Yoshida, M., Tanioka, F., Ogawa, H., et al. (2007). Solid-papillary carcinoma of the breast: Clinicopathological study of 20 cases. Pathology International, 57, 421–429.
Piscuoglio, S., Ng, C. K. Y., Martelotto, L. G., Eberle, C. A., Cowell, C. F., Natrajan, R., Bidard, F. C., et al. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular Oncology, 8, 1588–1602.
Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787–793.
Tan, B. Y., Thike, A. A., Ellis, I. O., & Tan, P. H. (2016). Clinicopathologic characteristics of solid papillary carcinoma of the breast. American Journal of Surgical Pathology, 40, 1334–1342.
Turashvili, G., Brogi, E., Morrow, M., Hudis, C., Dickler, M., Norton, L., & Wen, H. Y. (2017). The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis. Breast Cancer Research and Treatment, 165, 65–76.
Wei, S. (2016). Papillary lesions of the breast: An update. Archives of Pathology & Laboratory Medicine, 140, 628–643.
Yoshimura, N., Murakami, S., Kaneko, M., Sakatani, A., Hirabayashi, N., & Takiyama, W. (2013). Synchronous bilateral solid papillary carcinomas of the breast. Case Reports in Surgery, 2013, 812129.
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Vissio, E., Marchiò, C., Sapino, A. (2020). Solid Papillary Carcinoma. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4760
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DOI: https://doi.org/10.1007/978-3-319-62539-3_4760
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