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Ductal Adenoma

  • Reference work entry
  • First Online:
Breast Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 1230 Accesses

Synonyms

Sclerosing Papilloma is used as a synonym in WHO 2012 (Foschini et al. 2012).

Definition

Solid benign tumor of the breast ducts, involving small or medium size ducts described by Azzopardi and Salm (Azzopardi and Salm 1984). These lesions may rarely arise from large-sized ducts (Lammie and Millis 1989).

Clinical Features

  • Incidence

    It is an uncommon disease.

  • Age

    It is most frequently seen in women over 50 years.

  • Sex

    Female

  • Site

    Mostly unilateral, in the form of single or multiple nodules. Bilaterality has been reported in patients with Carney Syndrome (Carney and Stratakis 1996; Carney and Toorkey 1991)

  • Symptoms and Treatment

    Ductal adenoma may present as a palpable mass or sometimes with nipple discharge. On mammography, it is a well-delineated nodule, with smooth margins with or without coarse calcifications; ultrasonography may exhibit hypoechoic structure, sometimes located within a cyst and MR imaging shows smooth and clear margins (Matsubayashi et al. 2016). Excision is...

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References and Further Reading

  • Azzopardi, J. G., & Salm, R. (1984). Ductal adenoma of the breast: A lesion which can mimic carcinoma. Journal of Pathology, 144, 15–23. https://doi.org/10.1002/path.1711440103.

    Article  CAS  PubMed  Google Scholar 

  • Carney, J. A., & Stratakis, C. A. (1996). Ductal adenoma of the breast and the Carney complex. American Journal of Surgical Pathology, 20, 1154–1155.

    Article  CAS  PubMed  Google Scholar 

  • Carney, J. A., & Toorkey, B. C. (1991). Ductal adenoma of the breast with tubular features. A probable component of the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas. American Journal of Surgical Pathology, 15, 722–731.

    Article  CAS  PubMed  Google Scholar 

  • Foschini, M., Simpson, J., & O’Malley, F. (2012). Ductal adenoma. In S. Lakhani, I. Ellis, S. Schnitt, P. Tan, & M. Van de Vijyer (Eds.), WHO classification of tumors of the breast (pp. 117–118). Lyon: IARC.

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  • Lammie, G. A., & Millis, R. R. (1989). Ductal adenoma of the breast – A review of fifteen cases. Human Pathology, 20, 903–908.

    Article  CAS  PubMed  Google Scholar 

  • Matsubayashi, R. N., Momosaki, S., & Muranaka, T. (2016). Ductal adenoma of breast: imaging characteristics and radiologic-pathologic correlation of unique findings which reflect “pseudoinvasion”. Breast Cancer, 23, 597–606. https://doi.org/10.1007/s12282-015-0608-9.

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  • Troxell, M. L., Levine, J., Beadling, C., Warrick, A., Dunlap, J., Presnell, A., Patterson, J., Shukla, A., Olson, N. R., Heinrich, M. C., & Corless, C. L. (2010). High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Modern Pathology, 23, 27.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Pathology Department, Marmara University, Istanbul, Turkey

    Handan Kaya

Authors
  1. Handan Kaya
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Corresponding author

Correspondence to Handan Kaya .

Editor information

Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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Kaya, H. (2020). Ductal Adenoma. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4746

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  • DOI: https://doi.org/10.1007/978-3-319-62539-3_4746

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62538-6

  • Online ISBN: 978-3-319-62539-3

  • eBook Packages: MedicineReference Module Medicine

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