Synonyms
Sclerosing adenosis (SA)
Definition
SA is a lobulocentric proliferation of distorted acini around a central duct with preservation of myoepithelial cells, accompanied with varying degrees of epithelial atrophy and stromal fibrosis.
Clinical Features
Incidence
SA is often an incidental finding in breast tissue removed for other reasons. In autopsy studies performed on patients with no history of breast disease, the incidence of SA was in a range of 7–20%. The lesion is present in 12–28% of breast biopsies without cancer and in 5–7% of malignant biopsies.
Age
Most patients are in their forties and fifties with a peak in the 45–55 age group (34%), versus 28.3% of older women and 21.6% of women less than 45.
Sex
SA is predominant in women and more common in obese and in women using hormone replacement therapy and with a higher fibroglandular breast tissue density at mammography (>25%). Because of increased estrogen receptor (ER) expression observed compared with normal glandular...
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References and Further Reading
Jensen, R. A., Page, D. L., Dupont, W. D., & Rogers, L. W. (1989). Invasive breast cancer risk in women with sclerosing adenosis. Cancer, 64, 1977–1983.
Nassar, A., Hoskin, T. L., Stallings-Mann, M. L., Degnim, A. C., Radisky, D. C., Frost, M. H., Vierkant, R. A., Hartmann, L. C., & Visscher, D. W. (2015). Ki-67 expression in sclerosing adenosis and adjacent normal breast terminal ductal lobular units: A nested case-control study from the Mayo Benign Breast Disease Cohort. Breast Cancer Research and Treatment, 151, 89–97.
Pavlakis, K., Zoubouli, C., Liakakos, T., Messini, I., Keramopoullos, A., Athanassiadou, S., Kafousi, M., & Stathopoulos, E. N. (2006). Myoepithelial cell cocktail (P63+SMA) for the evaluation of sclerosing breast lesions. Breast, 15, 705–712.
Urban, J. A., & Adair, F. E. (1949). Sclerosing adenosis. Cancer, 2, 625–634.
Visscher, D. W., Nassar, A., Degnim, A. C., Frost, M. H., Vierkant, R. A., Frank, R. D., Tarabishy, Y., Radisky, D. C., & Hartmann, L. C. (2014). Sclerosing adenosis and risk of breast cancer. Breast Cancer Research and Treatment, 144, 205–212.
Winham, S. J., Mehner, C., Heinzen, E. P., Broderick, B. T., Stallings-Mann, M., Nassar, A., Vierkant, R. A., Hoskin, T. L., Frank, R. D., Wang, C., Denison, L. A., Vachon, C. M., Frost, M. H., Hartmann, L. C., Aubrey Thompson, E., Sherman, M. E., Visscher, D. W., Degnim, A. C., & Radisky, D. C. (2017). NanoString-based breast cancer risk prediction for women with sclerosing adenosis. Breast Cancer Research and Treatment, 166, 641–650.
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Pekar, G. (2020). Sclerosing Adenosis. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4734
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DOI: https://doi.org/10.1007/978-3-319-62539-3_4734
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