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Usual Ductal Hyperplasia (UDH)

  • Reference work entry
  • First Online:
Breast Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 1241 Accesses

Synonyms

Epithelial ductal hyperplasia; Epitheliosis; Florid ductal hyperplasia; Hyperplasia of usual type; Intraductal hyperplasia; Papillomatosis

Definition

Benign proliferative lesion within terminal ductal lobular units that typically shows lumen filled by cells arranged in a streaming-like fashion and peripheral slit-like spaces. Rarely usual ductal hyperplasia (UDH) may show an infiltrative pattern of growth.

Clinical Features

Impalpable lesion. No specific clinical features are described being a microscopic finding.

  • Incidence

    UDH is a common finding in fibrocystic changes of the breast and may be seen in papillomas.

  • Age

    All ages may be affected. Infiltrative epitheliosis is more frequent in postmenopausal age (range 54–80 years).

  • Sex

    It usually occurs in female breast, but it can be rarely observed in male breast.

  • Site

    No specific site is identified; this lesion can occur anywhere within the breast parenchyma.

  • Imaging

    Specific radiological patterns are not described for UDH....

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Notes

  1. 1.

    This encyclopedia includes no entries for V, W, X, Y and Z.

References and Further Reading

  • Ang, D. C., Warrick, A. L., Shilling, A., Beadling, C., Corless, C. L., & Troxell, M. L. (2014). Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions. Modern Pathology, 27, 740–750.

    Article  CAS  Google Scholar 

  • Eberle, C. A., Piscuoglio, S., Rakha, E. A., Ng, C. K., Geyer, F. C., Edelweiss, M., Sakr, R. A., Weigelt, B., Reis-Filho, J. S., & Ellis, I. O. (2016). Infiltrating epitheliosis of the breast: Characterization of histological features, immunophenotype and genomic profile. Histopathology, 68, 1030–1039.

    Article  Google Scholar 

  • Eusebi, V., & Millis, R. R. (2010). Epitheliosis, infiltrating epitheliosis, and radial scar. Seminar in Diagnotic Pathology, 27, 5–12.

    Article  Google Scholar 

  • Martinez, A. P., Cohen, C., Hanley, K. Z., & Li, X. B. (2016). Estrogen receptor and cytokeratin 5 are reliable markers to separate usual ductal hyperplasia from atypical ductal hyperplasia and low-grade ductal carcinoma in situ. Archive of Pathology and Laboratory Medicine, 140, 686–689.

    Article  CAS  Google Scholar 

  • Otterbach, F., Bankfalvi, A., Bergner, S., Decker, T., Krech, R., & Boecker, W. (2000). Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology, 37, 232–240.

    Article  CAS  Google Scholar 

  • Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787–793.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO IRCCS, Candiolo, Italy

    Anna Sapino, Davide Balmativola, Maria Giulia Disanto & Caterina Marchiò

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino & Caterina Marchiò

  3. Institut Curie, Paris, France

    Caterina Marchiò

Authors
  1. Anna Sapino
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  2. Davide Balmativola
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  3. Maria Giulia Disanto
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  4. Caterina Marchiò
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Corresponding author

Correspondence to Anna Sapino .

Editor information

Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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Sapino, A., Balmativola, D., Disanto, M.G., Marchiò, C. (2020). Usual Ductal Hyperplasia (UDH). In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4731

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  • DOI: https://doi.org/10.1007/978-3-319-62539-3_4731

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62538-6

  • Online ISBN: 978-3-319-62539-3

  • eBook Packages: MedicineReference Module Medicine

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