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Phyllodes Tumor

  • Reference work entry
  • First Online:
Breast Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Benign phyllodes tumor; Benign phylloides tumor; Borderline phyllodes tumor; Borderline phylloides tumor; Cystosarcoma phyllodes; Cystosarcoma phylloides; Malignant phyllodes tumor; Malignant phylloides tumor; Phyllodes tumor; Phylloides tumor

Definition

Phyllodes tumors are true fibroepithelial neoplasms characterized by a biphasic growth pattern which comprises an epithelial and a stromal component and resembles an intracanalicular fibroadenoma. The epithelial component is double layered and arranged in clefts and is surrounded by the hypercellular stromal component. Together these give the appearance of leaflike structures. This appearance is the origin of the name cystosarcoma phyllodes when they were first described in 1838 by Müller (phyllos being the Greek word for leaf, cysto- pertaining to the cystic spaces identified, and sarcomapertaining to the sarcomatous stroma). The lesion was initially described as benign, and it was not until 1931 that its malignant...

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References and Further Reading

  • Cimino-Mathews, A., Sharma, R., Illei, P. B., Vang, R., & Argani, P. (2014). A subset of malignant phyllodes tumors express p63 and p40: A diagnostic pitfall in breast core needle biopsies. American Journal of Surgical Pathology, 38, 1689–1696.

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  • Ellis, I., Lee, A., Pinder, S., & Rakha, E. (2013). Tumors of the breast. In C. Fletcher (Ed.), Diagnostic histopathology of tumors (4th ed., pp. 1064–1065). Philadelpia: Elsevier.

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  • Jara-Lazaro, A. R., Akhilesh, M., Thike, A. A., Lui, P. C.-W., Tse, G. M.-K., & Tan, P. H. (2010). Predictors of phyllodes tumours on core biopsy specimens of fibroepithelial neoplasms. Histopathology, 57, 220–232.

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  • Tan, P. H., Tse, G., & Kee, A. (2012). Fibroepithelial tumours. In S. Lakhani, I. Ellis, S. Schnitt, P. H. Tan, & M. van de Vijver (Eds.), WHO classification of tumours of the breast (4th ed., pp. 143–147). Geneva: World Health Organisation.

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  • Tan, B. Y., Acs, G., Apple, S. K., Badve, S., Bleiweiss, I. J., Brogi, E., … Tan, P. H. (2016). Phyllodes tumours of the breast: A consensus review. Histopathology, 68, 5–21.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Discipline of Pathology, NUI Galway, Galway, Ireland

    Mark O’Loughlin & Grace Callagy

  2. NUI Galway Clinical Science Institute, Galway, Ireland

    Grace Callagy

Authors
  1. Mark O’Loughlin
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  2. Grace Callagy
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Corresponding author

Correspondence to Mark O’Loughlin .

Editor information

Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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O’Loughlin, M., Callagy, G. (2020). Phyllodes Tumor. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4729

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  • DOI: https://doi.org/10.1007/978-3-319-62539-3_4729

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62538-6

  • Online ISBN: 978-3-319-62539-3

  • eBook Packages: MedicineReference Module Medicine

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