Synonyms
Polymorphous low-grade adenocarcinoma
Definition
Polymorphous carcinoma is a very rare breast carcinoma with epithelial cell differentiation showing morphological features similar to those referred as polymorphous low-grade adenocarcinoma in salivary glands.
Clinical Features
Incidence
Five cases of this special type of primary breast carcinoma have been reported in literature with morphological description.
Age
Median age at presentation is 55 years, ranging from 37 to 74 years.
Sex
All the patients reported in literature are female.
Site
Breast without the prevalence of a specific mammary quadrant.
Treatment
Wide excision with axillary lymph node dissection is the choice of treatment of the cases reported in the literature, followed by radiotherapy in two patients. Although no lymph node metastases are found, polymorphous carcinoma seems to be an aggressive neoplasm and recommended treatment consists of wide excision with sentinel node biopsy and eventually axillary lymph...
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References
Asioli, S., Marucci, G., Ficarra, G., Stephens, M., Foschini, M. P., Ellis, I. O., & Eusebi, V. (2006). Polymorphous adenocarcinoma of the breast. Report of three cases. Virchows Archiv, 448, 29–34.
Elston, C. W., & Ellis, I. O. (1991). Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology, 19, 403–410.
Foschini, M. P., Morandi, L., Asioli, S., Giove, G., Corradini, A. G., & Eusebi, V. (2017). The morphological spectrum of salivary gland type tumours of the breast. Pathology, 49, 215–227.
Reyes, C., Jorda, M., & Gomez-Fernández, C. (2013). Salivary gland-like tumors of the breast express basal-type immunohistochemical markers. Applied Immunohistochemistry and Molecular Morphology, 21, 283–286.
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Asioli, S., Ricci, C. (2020). Polymorphous Carcinoma. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4727
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DOI: https://doi.org/10.1007/978-3-319-62539-3_4727
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