Synonyms
Lobular carcinoma in situ (LCIS); Lobular intraepithelial neoplasia (LIN)
Definition
Lobular carcinoma in situ (LCIS) is characterized by a neoplastic proliferation of small, uniform, dyscohesive cells that expands at least 50% of one terminal ductal-lobular unit (TDLU). Although the first pictures of “atypical proliferation of acinar cells” were published in 1919 by Ewing, the term LCIS was introduced in 1941 by Foote and Stewart to describe the histological hallmarks of this lesion within breast lobules. The description was restricted to a well-developed example of classic LCIS (LCIS-C) as an established histopathological entity. In 1985, Dupont and Page described the earlier stages of this lesion, such as atypical lobular hyperplasia (ALH). The term lobular neoplasia (LN) denotes the full spectrum of proliferation of the characteristic “lobular” cells in acini with frequent coexistence of ALH and LCIS (Haagensen et al. 1978). Additionally, the lobular neoplastic lesions...
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References and Further Reading
Haagensen, C. D., Lane, N., Lattes, R., & Bodian, C. (1978). Lobular neoplasia (so-called lobular carcinoma in situ) of the breast. Cancer, 42, 737–769.
King, T. A., Pilewskie, M., Muhsen, S., Patil, S., Mautner, S. K., Park, A., Oskar, S., Guerini-Rocco, E., Boafo, C., Gooch, J. C., De Brot, M., Reis-Filho, J. S., Morrogh, M., Andrade, V. P., Sakr, R. A., & Morrow, M. (2015). Lobular carcinoma in situ: A 29-year longitudinal experience evaluating clinicopathologic features and breast cancer risk. Journal of Clinical Oncology, 33, 3945–3952.
Mastracci, T. L., Tjan, S., Bane, A. L., O’malley, F. P., & Andrulis, I. L. (2005). E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast. Modern Pathology, 18, 741–751.
Pieri, A., Harvey, J., & Bundred, N. (2014). Pleomorphic lobular carcinoma in situ of the breast: Can the evidence guide practice? World Journal of Clinical Oncology, 5, 546–553.
Simpson, P. T., Reis-Filho, J. S., Gale, T., & Lakhani, S. R. (2005). Molecular evolution of breast cancer. Journal of Pathology, 205, 248–254.
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Pekar, G. (2020). Lobular In Situ Neoplasia. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4722
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DOI: https://doi.org/10.1007/978-3-319-62539-3_4722
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