Synonyms
Diabetic mastopathy; Lymphocytic mastitis; Sclerosing lymphocytic lobulitis
Definition
Diabetic Mastopathy (DMP), also known as lymphocytic mastitis or sclerosing lymphocytic lobulitis, is a relatively rare, fibro-inflammatory complication of diabetes mellitus (DM) (insulin-dependent diabetes of early onset and long duration), Hashimoto thyroiditis, Sjogren’s disease, and other autoimmune disorders (Weidner and Dabbs 2012). Soler and Khardori were the first to describe the entity in 1984. They reported 12 cases of DMP in a group of female patients, aged 25–40 years, with type I DM of 8–30 years from onset. The complications registered included limited mobility of the small joints of the hand, and neuro-, retino-, and nephropathy. The authors reported tumor-like lumps in the breast, which clinically mimicked carcinoma, but on histology, the lesion proved benign (Soler and Khardori 1984).
The term “diabetic mastopathy” was introduced by Byrd et al., who described the presence of...
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Byrd, B. F., Hartman, W. H., Graham, L. S., & Hogle, H. H. (1987). Mastopathy in insulin-dependent diabetics. Annals of Surgery, 205, 529–532.
Camuto, P. M., Zetrenne, E., & Ponn, T. (2000). Diabetic mastopathy. A report of 5 cases and a review of the literature. Archives of Surgery, 135, 1190–1193.
Foschini, M. P., Cavazza, A., Macedo Pinto, I. M., & Eusebi, V. (1990). Diabetic fibrous mastopathy. Report of two cases. Virchows Archiv. A, Pathological Anatomy and Histopathology, 417(6), 529–532.
Lammie, G. A., Bobrow, L. G., Staunton, M. D., Levison, D. A., Page, G., & Millis, R. R. (1991). Sclerosing lymphocytic lobulitis of the breast – Evidence for an autoimmune pathogenesis. Histopathology, 19(1), 13–20.
Lee, A. H. S., Zafrani, B., Kafiri, G., Rozan, S., & Millis, R. R. (1996). Sclerosing lymphocytic lobulitis in the male breast. Journal of Clinical Pathology, 49, 609–611.
Rosen, P. P. (2009). Inflammatory and reactive tumors. In P. P. Rosen (Ed.), Rosen’s breast pathology (3rd ed., pp. 33–70). Philadelphia: Lippincott Williams & Wilkins.
Soler, N. G., & Khardori, R. (1984). Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet, 1(8370), 193–195.
Tomaszewski, J. E., Brooks, J. S., Hicks, D., & Livolsi, V. A. (1992). Diabetic mastopathy: A distinctive clinicopathologic entity. Human Pathology, 23, 780–786.
Weidner, N., & Dabbs, D. J. (2012). Reactive and inflammatory conditions of the breast. In D. J. Dabbs (Ed.), Breast pathology (pp. 22–33). Philadelphia: Saunders.
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Popovska, S., Ivanov, I., Eusebi, V. (2020). Diabetic Mastopathy. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4704
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DOI: https://doi.org/10.1007/978-3-319-62539-3_4704
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